Zaucha Jan, Heddle Jonathan G
Departament of Computer Science, University of Bristol, Life Sciences Building, 24 Tyndall Avenue, Bristol BS8 1TQ, United Kingdom.
Bionanoscience and Biochemistry Laboratory, Jagiellonian University, Malopolska Centre of Biotechnology, Gronstajowa 7A, 30-387 Kraków, Poland.
Comput Struct Biotechnol J. 2017 May 30;15:351-358. doi: 10.1016/j.csbj.2017.05.002. eCollection 2017.
Biological molecules, like organisms themselves, are subject to genetic drift and may even become "extinct". Molecules that are no longer extant in living systems are of high interest for several reasons including insight into how existing life forms evolved and the possibility that they may have new and useful properties no longer available in currently functioning molecules. Predicting the sequence/structure of such molecules and synthesizing them so that their properties can be tested is the basis of "molecular resurrection" and may lead not only to a deeper understanding of evolution, but also to the production of artificial proteins with novel properties and even to insight into how life itself began.
生物分子与生物体自身一样,会受到基因漂变的影响,甚至可能“灭绝”。不再存在于生命系统中的分子因多种原因而备受关注,包括有助于深入了解现有生命形式的进化过程,以及它们可能具有当前功能分子所没有的新的有用特性。预测此类分子的序列/结构并进行合成,以便测试其特性,这是“分子复活”的基础,不仅可能带来对进化的更深入理解,还可能催生具有新特性的人工蛋白质,甚至有助于洞察生命本身的起源。