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甲状腺髓样癌转移至乳腺:一例报告及文献复习

Medullary carcinoma of the thyroid metastatic to the breast: a case report and literature review.

作者信息

Martins Sebastião Nunes, Giannotti Marcelo Abrantes, Siqueira Sheila Aparecida Coelho

机构信息

Department of Pathology- Faculdade de Medicina - Universidade de São Paulo - São Paulo/SP - Brazil.

出版信息

Autops Case Rep. 2014 Mar 31;4(1):53-57. doi: 10.4322/acr.2014.008. eCollection 2014 Jan-Mar.

DOI:10.4322/acr.2014.008
PMID:28652993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5470565/
Abstract

Breast malignancies, apart from skin cancer, are the leading cause of cancer from cancer among the female population. Unlike the high prevalence of primary mammary malignancies, metastases to the breast are uncommon, and account for only 0.2-2.7% of all malignancies affecting this organ. We report the case of a 35-year-old woman who sought medical care because of a breast lump. A mammogram suggested a breast tumor, which was biopsied. The histopathological workup resulted in the diagnosis of a metastasis from a medullary thyroid cancer. The authors review the most useful clinical, radiological, histological, and immunohistochemical features concerning extramammary malignancy to the breast.

摘要

除皮肤癌外,乳腺恶性肿瘤是女性人群中癌症相关死亡的主要原因。与原发性乳腺恶性肿瘤的高发病率不同,乳腺转移瘤并不常见,仅占影响该器官的所有恶性肿瘤的0.2 - 2.7%。我们报告一例35岁女性因乳腺肿块就医的病例。乳房X光检查提示乳腺肿瘤,遂进行活检。组织病理学检查结果诊断为甲状腺髓样癌转移。作者回顾了关于乳腺外恶性肿瘤转移至乳腺的最有用的临床、放射学、组织学和免疫组化特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac7e/5470565/04c9a4b78ed3/autopsy-04-01053-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac7e/5470565/1205f66a447c/autopsy-04-01053-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac7e/5470565/932ae3f68f8f/autopsy-04-01053-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac7e/5470565/04c9a4b78ed3/autopsy-04-01053-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac7e/5470565/1205f66a447c/autopsy-04-01053-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac7e/5470565/932ae3f68f8f/autopsy-04-01053-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac7e/5470565/04c9a4b78ed3/autopsy-04-01053-g03.jpg

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Endocr Pathol. 2013 Dec;24(4):220-8. doi: 10.1007/s12022-013-9265-8.
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Breast metastasis from a pulmonary adenocarcinoma: Case report and review of the literature.肺腺癌的乳腺转移:病例报告及文献复习
Oncol Lett. 2013 Jan;5(1):328-332. doi: 10.3892/ol.2012.995. Epub 2012 Oct 25.
3
Fine-needle aspiration cytology diagnosis of metastatic nonhaematological neoplasms of the breast: a series of seven cases.
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Diagn Cytopathol. 2012 Apr;40(4):297-304. doi: 10.1002/dc.21559. Epub 2010 Nov 2.
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Prognostic value of proliferation assay in the luminal, HER2-positive, and triple-negative biologic classes of breast cancer.在乳腺癌的腔面型、HER2 阳性和三阴性生物学分类中,增殖测定的预后价值。
Breast Cancer Res. 2012 Jan 6;14(1):R3. doi: 10.1186/bcr3084.
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Will molecular classification replace traditional breast pathology?分子分类会取代传统的乳腺病理学吗?
Int J Surg Pathol. 2010 Jun;18(3 Suppl):162S-166S. doi: 10.1177/1066896910370771.
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Immunostaining of gastric cancer with neuroendocrine differentiation: Reg IV-positive neuroendocrine cells are associated with gastrin, serotonin, pancreatic polypeptide and somatostatin.免疫组化染色显示胃神经内分泌分化癌:REG IV 阳性神经内分泌细胞与胃泌素、血清素、胰多肽和生长抑素有关。
Pathol Int. 2010 Apr;60(4):291-7. doi: 10.1111/j.1440-1827.2010.02519.x.
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Characteristics of metastasis in the breast from extramammary malignancies.乳房外恶性肿瘤转移的特征。
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Microarray-based gene expression profiling as a clinical tool for breast cancer management: are we there yet?基于微阵列的基因表达谱分析作为乳腺癌管理的临床工具:我们做到了吗?
Int J Surg Pathol. 2009 Aug;17(4):285-302. doi: 10.1177/1066896908328577. Epub 2008 Dec 22.
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Breast metastasis by medullary thyroid carcinoma detected by FDG positron emission tomography.通过氟代脱氧葡萄糖正电子发射断层扫描检测到的甲状腺髓样癌的乳腺转移。
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