Fatma Saadallah, Maha Chrigui, Ines Zemni, Salma Kammoun, Yoldez Houcin, Souhail Jbeli, Maha Driss, Tarak Ben Dhiab
Department of Surgical Oncology, Salah Azaiez Institute, Faculty of Medicine of Tunis, University of Tunis El Manar, Boulevad 9 Avril Bab Saadoun 1006, Tunis, Tunisia.
Laboratory of Microorganisms and Active Biomolecules, Sciences Faculty of Tunis, University of Tunis El Manar, Tunis, Tunisia.
BMC Womens Health. 2025 Jan 20;25(1):29. doi: 10.1186/s12905-025-03564-y.
Medullary thyroid carcinoma is a neuroendocrine tumor derived from thyroid C-cells. It is a rare aggressive tumor, known to metastasize to lymph nodes, liver, bones, and lungs. We report a case of a young patient with a family history of breast cancer, who developed breast metastases six months post-treatment for medullary thyroid carcinoma. The breast lesion was initially considered benign in ultrasound. Unlike the high prevalence of primary mammary malignancies, metastases to the breast are uncommon, and account for only 0.2-2.7% of all malignancies affecting this organ. This case emphasizes the need for thorough and continuous monitoring of patients with Medullary thyroid carcinoma, even in unusual locations, to ensure early detection and appropriate management. New lesions on imaging should be interpreted with caution to avoid underdiagnosing metastasis. Immunohistochemical analysis confirmed the metastatic origin, underscoring the challenges in distinguishing between primary and secondary breast tumors. This case contributes to the limited literature on MTC breast metastases and advocates for heightened clinical awareness regarding atypical metastatic sites in thyroid cancer patients.
甲状腺髓样癌是一种起源于甲状腺C细胞的神经内分泌肿瘤。它是一种罕见的侵袭性肿瘤，已知会转移至淋巴结、肝脏、骨骼和肺部。我们报告了一例有乳腺癌家族史的年轻患者，该患者在接受甲状腺髓样癌治疗六个月后出现了乳腺转移。乳腺病变在超声检查中最初被认为是良性的。与原发性乳腺恶性肿瘤的高发病率不同，乳腺转移并不常见，仅占所有累及该器官恶性肿瘤的0.2 - 2.7%。该病例强调了对甲状腺髓样癌患者进行全面和持续监测的必要性，即使在不寻常的部位，以确保早期发现和适当管理。影像学上新出现的病变应谨慎解读，以避免漏诊转移。免疫组织化学分析证实了转移起源，凸显了区分原发性和继发性乳腺肿瘤的挑战。该病例为关于甲状腺髓样癌乳腺转移的有限文献做出了贡献，并倡导提高对甲状腺癌患者非典型转移部位的临床认识。
