Kheifets Aaron, Freestone David, Gallistel C R
Department of Psychology, Rutgers University.
Department of Psychology, Brown University.
J Exp Anal Behav. 2017 Jul;108(1):39-72. doi: 10.1002/jeab.261. Epub 2017 Jun 27.
In three experiments with mice ( Mus musculus ) and rats (Rattus norvigicus), we used a switch paradigm to measure quantitative properties of the interval-timing mechanism. We found that: 1) Rodents adjusted the precision of their timed switches in response to changes in the interval between the short and long feed latencies (the temporal goalposts). 2) The variability in the timing of the switch response was reduced or unchanged in the face of large trial-to-trial random variability in the short and long feed latencies. 3) The adjustment in the distribution of switch latencies in response to changes in the relative frequency of short and long trials was sensitive to the asymmetry in the Kullback-Leibler divergence. The three results suggest that durations are represented with adjustable precision, that they are timed by multiple timers, and that there is a trial-by-trial (episodic) record of feed latencies in memory.
在对小鼠（小家鼠）和大鼠（褐家鼠）进行的三项实验中，我们使用了一种切换范式来测量间隔计时机制的定量特性。我们发现：1）啮齿动物会根据短喂食潜伏期和长喂食潜伏期（时间标杆）之间间隔的变化来调整其定时切换的精度。2）面对短喂食潜伏期和长喂食潜伏期在不同试验间的巨大随机变异性，切换反应的时间变异性会降低或保持不变。3）响应短试验和长试验相对频率的变化，切换潜伏期分布的调整对库尔贝克-莱布勒散度的不对称性敏感。这三个结果表明，持续时间是以可调整的精度来表征的，它们由多个定时器计时，并且在记忆中有每次试验（情景性）的喂食潜伏期记录。
