Ferrante Margherita, Pappalardo Anna Maria, Ferrito Venera, Pulvirenti Valentina, Fruciano Carmelo, Grasso Alfina, Sciacca Salvatore, Tigano Concetta, Copat Chiara
Department of Medical Sciences, Surgical and Advanced Technologies "G.F. Ingrassia", Hygiene and Public Health, University of Catania, Via Santa Sofia 87, Catania, Italy.
Department of Biological, Geological and Environmental Sciences, University of Catania, Via Androne 81, 95124 Catania, Italy.
Mar Pollut Bull. 2017 Sep 15;122(1-2):288-296. doi: 10.1016/j.marpolbul.2017.06.060. Epub 2017 Jun 24.
Heavy metal pollution is one of the greatest threats to the ecosystems because it degrades the habitat and is potentially toxic to wildlife and human populations. In the last few decades, bioaccumulation studies performed with a multimarker approach have been a valuable tool for the investigation of environmental and animal safety. We perform an analysis of a benthic teleost fish species - Parablennius sanguinolentus - sampled at several Italian coastal sites with different degrees of anthropogenic pressure. Our integrative analysis encompasses bioaccumulation of 10 metals, biomarkers of environmental stress (micronuclei and nuclear abnormalities) and neutral genetic variation (using sequences of the mtDNA control region). We find a clear and significant correlation of metal bioaccumulation with micronuclei and nuclear abnormalities, especially with undisputed genotoxic metals, such as Cd, Cr, Hg and Pb. Furthermore, the molecular genetic analysis revealed a decrease of genetic variability in the populations more subjected to anthropic pressure.
重金属污染是对生态系统最大的威胁之一，因为它会破坏栖息地，对野生动物和人类种群具有潜在毒性。在过去几十年中，采用多标记方法进行的生物累积研究一直是调查环境和动物安全的宝贵工具。我们对一种底栖硬骨鱼类——红纹副鳚进行了分析，该鱼在意大利几个受不同程度人为压力影响的沿海地点采样。我们的综合分析包括10种金属的生物累积、环境应激生物标志物（微核和核异常）以及中性遗传变异（使用线粒体DNA控制区序列）。我们发现金属生物累积与微核和核异常之间存在明显且显著的相关性，特别是与无可争议的基因毒性金属，如镉、铬、汞和铅。此外，分子遗传分析表明，受人为压力影响更大的种群的遗传变异性降低。
