Kobayashi Katsuhiro, Akiyama Tomoyuki, Agari Takashi, Sasaki Tatsuya, Shibata Takashi, Hanaoka Yoshiyuki, Akiyama Mari, Endoh Fumika, Oka Makio, Date Isao
Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558,
Acta Med Okayama. 2017 Jun;71(3):191-200. doi: 10.18926/AMO/55201.
Electroencephalogram (EEG) data include broadband electrical brain activity ranging from infra-slow bands (< 0.1 Hz) to traditional frequency bands (e.g., the approx. 10 Hz alpha rhythm) to high-frequency bands of up to 500 Hz. High-frequency oscillations (HFOs) including ripple and fast ripple oscillations (80-200 Hz and>200 / 250 Hz, respectively) are particularly of note due to their very close relationship to epileptogenicity, with the possibility that they could function as a surrogate biomarker of epileptogenicity. In contrast, physiological high-frequency activity plays an important role in higher brain functions, and the differentiation between pathological / epileptic and physiological HFOs is a critical issue, especially in epilepsy surgery. HFOs were initially recorded with intracranial electrodes in patients with intractable epilepsy as part of a long-term invasive seizure monitoring study. However, fast oscillations (FOs) in the ripple and gamma bands (40-80 Hz) are now noninvasively detected by scalp EEG and magnetoencephalography, and thus the scope of studies on HFOs /FOs is rapidly expanding.
脑电图（EEG）数据包括从超慢波段（<0.1赫兹）到传统频段（如约10赫兹的阿尔法节律）再到高达500赫兹的高频段的宽带脑电活动。高频振荡（HFOs），包括涟漪振荡和快速涟漪振荡（分别为80 - 200赫兹和>200 / 250赫兹），因其与致痫性的密切关系而备受关注，它们有可能作为致痫性的替代生物标志物。相比之下，生理性高频活动在高级脑功能中起重要作用，区分病理性/癫痫性和生理性HFOs是一个关键问题，尤其是在癫痫手术中。HFOs最初是在难治性癫痫患者中通过颅内电极记录的，作为长期侵入性癫痫发作监测研究的一部分。然而，现在通过头皮脑电图和脑磁图可以无创检测到涟漪和伽马波段（40 - 80赫兹）的快速振荡（FOs），因此关于HFOs / FOs的研究范围正在迅速扩大。
