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急性髓系白血病骨髓移植后IgA肾病完全缓解。

Complete remission of IgA nephropathy after bone marrow transplantation for acute myeloid leukaemia.

作者信息

Park Eun-Kyung, Jeon Jin-Seok, Noh Hyun-Jin, Won Jong-Ho, Park Hee-Sook

机构信息

Department of Internal Medicine, University of Soon Chun Hyang School of Medicine, Seoul, Korea.

出版信息

NDT Plus. 2008 Dec;1(6):420-422. doi: 10.1093/ndtplus/sfn147. Epub 2008 Sep 15.

DOI:10.1093/ndtplus/sfn147
PMID:28657023
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5477877/
Abstract

IgA nephropathy is the most common primary glomerulonephritis, but the pathogenesis of IgA nephropathy is still unclear. A 32-year-old woman was found to have IgA nephropathy and acute myeloid leukaemia. She was treated with allogenic bone marrow transplantation (BMT). After BMT, immunoflourescent staining of IgA and proteinuria disappeared. These findings suggest bone marrow cells are involved in the pathogenesis of IgA nephropathy. We herein report a case of complete remission of IgA nephropathy after BMT for acute myeloid leukaemia.

摘要

IgA肾病是最常见的原发性肾小球肾炎，但IgA肾病的发病机制仍不清楚。一名32岁女性被发现患有IgA肾病和急性髓系白血病。她接受了异基因骨髓移植（BMT）治疗。BMT后，IgA免疫荧光染色和蛋白尿消失。这些发现提示骨髓细胞参与了IgA肾病的发病机制。我们在此报告一例急性髓系白血病患者在接受BMT后IgA肾病完全缓解的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/609c/5477877/587878c86c3d/sfn147fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/609c/5477877/587878c86c3d/sfn147fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/609c/5477877/587878c86c3d/sfn147fig1.jpg

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本文引用的文献

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Th1 polarization in murine IgA nephropathy directed by bone marrow-derived cells.骨髓来源细胞介导的小鼠IgA肾病中的Th1极化
Kidney Int. 2007 Aug;72(3):319-27. doi: 10.1038/sj.ki.5002300. Epub 2007 May 9.
2
Stem cells and cardiovascular and renal disease: today and tomorrow.干细胞与心血管及肾脏疾病：现状与未来。
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Stem cells and kidney diseases.干细胞与肾脏疾病
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Progress in Pathogenesis of Immunoglobin A Nephropathy.免疫球蛋白A肾病发病机制的研究进展
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Roles of bone marrow cells in glomerular diseases.骨髓细胞在肾小球疾病中的作用。
Clin Exp Nephrol. 2003 Sep;7(3):179-85. doi: 10.1007/s10157-003-0248-9.
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IgA nephropathy.IgA肾病
N Engl J Med. 2002 Sep 5;347(10):738-48. doi: 10.1056/NEJMra020109.
6
Stem cells in renal biology: bone marrow transplantation for the treatment of IgA nephropathy.肾脏生物学中的干细胞：骨髓移植治疗IgA肾病。
Exp Nephrol. 2002;10(1):51-8. doi: 10.1159/000049898.
7
The potential of bone marrow-derived cells to differentiate to glomerular mesangial cells.骨髓来源细胞分化为肾小球系膜细胞的潜力。
J Am Soc Nephrol. 2001 Jul;12(7):1401-1409. doi: 10.1681/ASN.V1271401.
8
BMT beats autoimmune disease.骨髓移植战胜自身免疫性疾病。
Nat Med. 1998 Feb;4(2):153-5. doi: 10.1038/nm0298-153.
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Increased binding of polymeric lambda-IgA to cultured human mesangial cells in IgA nephropathy.在IgA肾病中，聚合型λ-IgA与培养的人系膜细胞的结合增加。
Kidney Int. 1996 Mar;49(3):839-45. doi: 10.1038/ki.1996.116.