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来自灵芝子实体的三萜类化合物。

Nortriterpenoids from the Fruiting Bodies of the Mushroom Ganoderma resinaceum.

作者信息

Chen Xian-Qiang, Chen Ling-Xiao, Zhao Jing, Tang Yu-Ping, Li Shao-Ping

机构信息

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China.

Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.

出版信息

Molecules. 2017 Jun 28;22(7):1073. doi: 10.3390/molecules22071073.

Abstract

is usually used as ethnomedicine for immune-regulation, hyperglycemia, and liver disease. To date, only a few chemical constituents have been reported from . . In this study, fifteen nortriterpenoids including six new nortriterpenoids (-) and nine known analogs (-), were separated and purified from the fruiting bodies of . . New compounds were identified as lucidone I (), lucidone J (), lucidone K (), lucidone I (), ganosineniol B (), and ganosineniol C (), based on analysis of extensive spectroscopic data (high resolution mass spectrometry (HRMS), nuclear magnetic resonance (NMR), infrared (IR), and ultraviolet (UV)). The known compounds were assigned as lucidone A (), lucidone B (), lucidone H (), lucidone E (), lucidone F (), lucidone D (), lucidone C (), ganoderense F (), and ganosineniol A (), by comparing their spectroscopic data with those reported in the literature. Compounds , , and - were examined for -glucosidase inhibitory activity and display no significant activity, but the finding may support that the side chain of ganoderma triterpenoids played an important role in -glucosidase inhibitory activity.

摘要

通常被用作民族药物来调节免疫、治疗高血糖和肝脏疾病。迄今为止,仅从……报道了少数化学成分。在本研究中,从……的子实体中分离并纯化出15种降三萜类化合物,包括6种新的降三萜类化合物(-)和9种已知类似物(-)。基于广泛的光谱数据(高分辨率质谱(HRMS)、核磁共振(NMR)、红外(IR)和紫外(UV))分析,新化合物被鉴定为亮菌甲素I()、亮菌甲素J()、亮菌甲素K()、亮菌甲素I()、灵芝烯醇B()和灵芝烯醇C()。通过将已知化合物的光谱数据与文献报道的数据进行比较,已知化合物被鉴定为亮菌甲素A()、亮菌甲素B()、亮菌甲素H()、亮菌甲素E()、亮菌甲素F()、亮菌甲素D()、亮菌甲素C()、灵芝酮F()和灵芝烯醇A()。对化合物……和……进行了α-葡萄糖苷酶抑制活性检测,结果显示无显著活性,但这一发现可能支持灵芝三萜类化合物的侧链在α-葡萄糖苷酶抑制活性中起重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0111/6152414/3d4d25631578/molecules-22-01073-g001.jpg

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