Rtimi Sami, Giannakis Stefanos, Pulgarin Cesar
Group of Advanced Oxidation Processes, Swiss Federal Institute of Technology, EPFL-SB-ISIC-GPAO, Station 6, CH-1015 Lausanne, Switzerland.
Molecules. 2017 Jun 28;22(7):1074. doi: 10.3390/molecules22071074.
This review addresses the preparation of antibacterial 2D textile and thin polymer films and 3D surfaces like catheters for applications in hospital and health care facilities. The sputtering of films applying different levels of energy led to the deposition of metal/oxide/composite/films showing differentiated antibacterial kinetics and surface microstructure. The optimization of the film composition in regards to the antibacterial active component was carried out in each case to attain the fastest antibacterial kinetics, since this is essential when designing films avoiding biofilm formation (under light and in the dark). The antimicrobial performance of these sputtered films on (MRSA) and () were tested. A protecting effect of TiO₂ was found for the release of Cu by the TiO₂-Cu films compared to films sputtered by Cu only. The Cu-released during bacterial inactivation by TiO₂-Cu was observed to be much lower compared to the films sputtered only by Cu. The FeOx-TiO₂-PE films induced inactivation under solar or under visible light with a similar inactivation kinetics, confirming the predominant role of FeOx in these composite films. By up-to-date surface science techniques were used to characterize the surface properties of the sputtered films. A mechanism of bacteria inactivation is suggested for each particular film consistent with the experimental results found and compared with the literature.
本综述探讨了用于医院和医疗保健设施的抗菌二维纺织物和聚合物薄膜以及三维表面（如导管）的制备。对施加不同能量水平的薄膜进行溅射，导致金属/氧化物/复合材料/薄膜的沉积，这些薄膜表现出不同的抗菌动力学和表面微观结构。针对每种情况，都对薄膜成分中抗菌活性成分进行了优化，以实现最快的抗菌动力学，因为在设计避免生物膜形成（在光照和黑暗条件下）的薄膜时，这一点至关重要。测试了这些溅射薄膜对耐甲氧西林金黄色葡萄球菌（MRSA）和大肠杆菌（）的抗菌性能。与仅由铜溅射的薄膜相比，发现TiO₂ - Cu薄膜对铜的释放具有保护作用。观察到在TiO₂ - Cu使细菌失活过程中释放的铜比仅由铜溅射的薄膜低得多。FeOx - TiO₂ - PE薄膜在太阳光或可见光下诱导细菌失活，且失活动力学相似，这证实了FeOx在这些复合薄膜中的主要作用。通过最新的表面科学技术对溅射薄膜的表面性质进行了表征。针对每种特定薄膜，提出了一种与所发现的实验结果一致并与文献相比较的细菌失活机制。
