Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
J Cell Biochem. 2018 Jan;119(1):185-196. doi: 10.1002/jcb.26244. Epub 2017 Oct 4.
Cancer is one of main health public problems worldwide. Several factors are involved in beginning and development of cancer. Genetic and internal/external environmental factors can be as important agents that effect on emerging and development of several cancers. Diet and nutrition may be as one of important factors in prevention or treatment of various cancers. A large number studies indicated that suitable dietary patterns may help to cancer prevention or could inhibit development of tumor in cancer patients. Moreover, a large numbers studies indicated that a variety of dietary compounds such as curcumin, green tea, folat, selenium, and soy isoflavones show a wide range anti-cancer properties. It has been showed that these compounds via targeting a sequence of cellular and molecular pathways could be used as suitable options for cancer chemoprevention and cancer therapy. Recently, dietary microRNAs and exosomes have been emerged as attractive players in cancer prevention and cancer therapy. These molecules could change behavior of cancer cells via targeting various cellular and molecular pathways involved in cancer pathogenesis. Hence, the utilization of dietary compounds which are associated with powerful molecules such as microRNAs and exosomes and put them in dietary patterns could contribute to prevention or treatment of various cancers. Here, we summarized various studies that assessed effect of dietary patterns on cancer prevention shortly. Moreover, we highlighted the utilization of dietary compounds, dietary microRNAs, and dietary exosomes and their cellular and molecular pathways in cancer chemoprevention.
癌症是全球主要的公共卫生问题之一。癌症的发生和发展涉及多种因素。遗传和内外环境因素可能是影响多种癌症发生和发展的重要因素。饮食和营养可能是预防或治疗各种癌症的重要因素之一。大量研究表明,适当的饮食模式有助于预防癌症,或可抑制癌症患者肿瘤的发展。此外,大量研究表明,姜黄素、绿茶、叶酸、硒和大豆异黄酮等多种膳食化合物具有广泛的抗癌特性。这些化合物通过靶向一系列细胞和分子途径,可以作为癌症化学预防和癌症治疗的合适选择。最近,膳食 microRNAs 和外泌体已成为癌症预防和癌症治疗的有吸引力的参与者。这些分子可以通过靶向参与癌症发病机制的各种细胞和分子途径来改变癌细胞的行为。因此,利用与 microRNAs 和外泌体等强大分子相关的膳食化合物,并将其纳入饮食模式,可能有助于预防或治疗各种癌症。在这里,我们简要总结了评估饮食模式对癌症预防影响的各种研究。此外,我们强调了膳食化合物、膳食 microRNAs 和膳食外泌体及其在癌症化学预防中的细胞和分子途径的利用。