Chiang Catheryne, Mahalingam Sharada, Flaws Jodi A
Department of Comparative Biosciences, University of Illinois, Urbana, Illinois.
Semin Reprod Med. 2017 May;35(3):241-249. doi: 10.1055/s-0037-1603569. Epub 2017 Jun 28.
This review article summarizes the epidemiological findings published between 2011 and 2016 concerning bisphenol A (BPA), phthalates, dioxins, pesticides, air pollution, fracking chemicals, triclosan, and parabens and fertility parameters in men (i.e., semen volume, sperm concentration, sperm motility, and sperm morphology) as well as fertility parameters in women (i.e., cyclicity, fertility treatment outcomes), pregnancy outcomes (i.e., preterm birth,miscarriage), and reproductive disorders (i.e., polycystic ovary syndrome, endometriosis, and uterine fibroids). Overall, this review indicates that several environmental toxicants are significantly associated with reduced fertility parameters in men and women as well as several reproductive disorders in women. Although many studies reported that the selected exposures are associated with adverse fertility outcomes, several studies reported null associations. Thus, future studies are still needed to better elucidate the associations and potential mechanisms between these environmental chemicals and fertility outcomes in men and women.
这篇综述文章总结了2011年至2016年间发表的关于双酚A（BPA）、邻苯二甲酸盐、二恶英、农药、空气污染、水力压裂化学品、三氯生和对羟基苯甲酸酯与男性生育参数（即精液量、精子浓度、精子活力和精子形态）以及女性生育参数（即月经周期、生育治疗结果）、妊娠结局（即早产、流产）和生殖系统疾病（即多囊卵巢综合征、子宫内膜异位症和子宫肌瘤）的流行病学研究结果。总体而言，该综述表明，几种环境毒物与男性和女性生育参数降低以及女性的几种生殖系统疾病显著相关。尽管许多研究报告称所选暴露因素与不良生育结局有关，但也有几项研究报告称无关联。因此，仍需要进一步的研究来更好地阐明这些环境化学物质与男性和女性生育结局之间的关联及潜在机制。
