Kim Dong-In, Kim Hakhyun, Son Purum, Kang Ji-Houn, Kang Byeong-Teck, Yang Mhan-Pyo
College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea.
J Vet Med Sci. 2017 Aug 10;79(8):1366-1373. doi: 10.1292/jvms.16-0647. Epub 2017 Jun 29.
The present study aimed to determine whether circulating serum concentrations of 25-hydroxyvitamin D [25-(OH) D] differed between healthy dogs and dogs with acute pancreatitis (AP). Twenty-two healthy dogs and twenty client-owned dogs with AP were enrolled in the study. Serum concentrations of 25-(OH) D, blood ionized calcium (iCa), and serum C-reactive protein (CRP) were measured. Concentrations of serum 25-(OH) D and blood iCa in dogs with AP were significantly lower than those of healthy dogs, and serum concentrations of CRP in dogs with AP were significantly higher than those of healthy dogs. A significant difference in 25-(OH) D serum concentrations was observed between survivor and non-survivor dogs with AP. After resolution of clinical signs, concentrations of serum 25-(OH) D, blood iCa, and serum CRP did not differ compared to those before treatment. This study shows that dogs with AP exhibit decreased 25-(OH) D levels, which might be associated with calcium imbalances and mortality rate in canine AP.
本研究旨在确定健康犬与患有急性胰腺炎（AP）的犬之间，循环血清中25-羟基维生素D [25-(OH) D] 的浓度是否存在差异。22只健康犬和20只患有AP的客户拥有犬被纳入本研究。测量了血清25-(OH) D、血液离子钙（iCa）和血清C反应蛋白（CRP）的浓度。患有AP的犬的血清25-(OH) D和血液iCa浓度显著低于健康犬，而患有AP的犬的血清CRP浓度显著高于健康犬。在患有AP的存活犬和非存活犬之间观察到25-(OH) D血清浓度存在显著差异。临床症状缓解后，血清25-(OH) D、血液iCa和血清CRP的浓度与治疗前相比没有差异。本研究表明，患有AP的犬表现出25-(OH) D水平降低，这可能与犬AP中的钙失衡和死亡率有关。
