维生素 D 受体多态性与急性胰腺炎的关系：系统评价和荟萃分析的方案。

Association between vitamin D receptor polymorphisms and acute pancreatitis: A protocol for systematic review and meta analysis.

机构信息

Department of Emergency.

Dental Department, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, China.

出版信息

Medicine (Baltimore). 2021 Apr 23;100(16):e25508. doi: 10.1097/MD.0000000000025508.

DOI:10.1097/MD.0000000000025508

PMID:33879686

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8078433/

Abstract

BACKGROUND

Several studies have been performed to investigate the association between vitamin D receptor (VDR) gene polymorphism and acute pancreatitis, but the results are inconclusive. We conducted this meta-analysis for a precise estimation of the association between BsmI (rs1544410), ApaI (rs7975232), TaqI (rs731236), and FokI (rs2228570) polymorphisms and acute pancreatitis.

METHODS

Appropriate studies were retrieved by searching Web of Science, PubMed, Scopus, and Google scholar databases, until January 31, 2021. Two reviewers independently conducted data extraction and literature quality evaluation. Odds ratios and 95% confidence intervals were calculated to evaluate the strength of the association.All of the data were analyzed with Stata 16.0.

RESULTS

The results of this meta-analysis will be submitted to a peer-reviewed journal for publication.

CONCLUSIONS

This meta-analysis will summarize the association between BsmI, ApaI, TaqI, and FokI polymorphisms and the risk of acute pancreatitis.

ETHICS AND DISSEMINATION

Ethical approval was not required for this study. The systematic review will be published in a peer-reviewed journal, presented at conferences, and shared on social media platforms.

OSF REGISTRATION NUMBER

DOI 10.17605/OSF.IO/83W7R.

摘要

背景

已有多项研究探讨了维生素 D 受体（VDR）基因多态性与急性胰腺炎之间的关联，但结果尚无定论。我们进行了这项荟萃分析，以更准确地评估 BsmI（rs1544410）、ApaI（rs7975232）、TaqI（rs731236）和 FokI（rs2228570）多态性与急性胰腺炎之间的关联。

方法

通过检索 Web of Science、PubMed、Scopus 和 Google Scholar 数据库，我们搜索到了截止到 2021 年 1 月 31 日的相关研究。两位审查员独立进行了数据提取和文献质量评估。使用比值比（OR）和 95%置信区间（CI）来评估关联的强度。所有数据均采用 Stata 16.0 进行分析。