Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu 610041, PR China.
Diabetes Res Clin Pract. 2010 Dec;90(3):352-7. doi: 10.1016/j.diabres.2010.09.017.
This study was to investigate the relationship of gamma-glutamyl transferase to ferritin, and their interaction on the risk of type 2 diabetes.
A total of 436 men and 588 women were recruited. According to levels of GGT and ferritin, they were divided into three groups in each gender of each geological location (Urban or Rural), that is, Group 1 (both GGT and ferritin<median values), Group 2 (only GGT or ferritin ≥ median values), and group 3 (both GGT and ferritin ≥ median values). Odds ratios for T2D in group 2-3 compared with group 1 were analyzed by multiple logistic regressions.
(1) The prevalence of glucose abnormalities increased across the three groups of female subjects. Correspondingly, MDA levels were also higher in group 3 than other groups. (2) GGT and ferritin were correlated with each other after controlling for BMI. (3) T2D risk was higher in group 3 than that in group 1 in female subjects, which was independent of age, BMI, and T2D family history.
GGT and ferritin were correlated with each other, and had synergetic effect on the risk of T2D in women. The mechanism might be involved in enhanced oxidative stress.
本研究旨在探讨γ-谷氨酰转移酶（GGT）与铁蛋白的关系及其相互作用对 2 型糖尿病（T2D）风险的影响。
共纳入 436 名男性和 588 名女性。根据 GGT 和铁蛋白水平，将每个性别和地理位置（城市或农村）的个体分为三组，即第 1 组（GGT 和铁蛋白均<中位数）、第 2 组（仅 GGT 或铁蛋白≥中位数）和第 3 组（GGT 和铁蛋白均≥中位数）。采用多因素 logistic 回归分析第 2-3 组与第 1 组相比 T2D 的比值比（OR）。
（1）女性受试者中，随着三组的划分，葡萄糖异常的患病率逐渐升高。相应地，第 3 组的丙二醛（MDA）水平也高于其他组。（2）在控制体重指数（BMI）后，GGT 和铁蛋白之间存在相关性。（3）在女性中，与第 1 组相比，第 3 组的 T2D 风险更高，且这种关联独立于年龄、BMI 和 T2D 家族史。
GGT 和铁蛋白相互关联，对女性 T2D 风险具有协同作用。其机制可能与增强的氧化应激有关。
