Maulik Malabika, Mitra Swarup, Bult-Ito Abel, Taylor Barbara E, Vayndorf Elena M
Department of Chemistry and Biochemistry, University of Alaska FairbanksFairbanks, AK, United States.
Department of Biology and Wildlife, University of Alaska FairbanksFairbanks, AK, United States.
Front Genet. 2017 Jun 13;8:77. doi: 10.3389/fgene.2017.00077. eCollection 2017.
Parkinson's disease (PD) is a neurodegenerative disorder with symptoms that progressively worsen with age. Pathologically, PD is characterized by the aggregation of α-synuclein in cells of the substantia nigra in the brain and loss of dopaminergic neurons. This pathology is associated with impaired movement and reduced cognitive function. The etiology of PD can be attributed to a combination of environmental and genetic factors. A popular animal model, the nematode roundworm , has been frequently used to study the role of genetic and environmental factors in the molecular pathology and behavioral phenotypes associated with PD. The current review summarizes cellular markers and behavioral phenotypes in transgenic and toxin-induced PD models of .
帕金森病（PD）是一种神经退行性疾病，其症状会随着年龄的增长而逐渐恶化。在病理上，PD的特征是大脑黑质细胞中α-突触核蛋白的聚集以及多巴胺能神经元的丧失。这种病理与运动障碍和认知功能减退有关。PD的病因可归因于环境和遗传因素的综合作用。一种常用的动物模型——线虫，经常被用于研究遗传和环境因素在与PD相关的分子病理学和行为表型中的作用。本综述总结了转基因和毒素诱导的PD模型中的细胞标志物和行为表型。
