Department of Chemical Engineering, National United University, Miaoli, Taiwan.
Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan.
Biomed Res Int. 2017;2017:5232680. doi: 10.1155/2017/5232680. Epub 2017 Jun 1.
Natural medical plant is considered as a good source of tyrosinase inhibitors. Red vine leaf extract (RVLE) can be applied to a wide variety of medical disciplines, such as treatments for chronic venous insufficiency over many decades. This study investigated the tyrosinase inhibitory activity of RVLE containing gallic acid, chlorogenic acid, epicatechin, rutin, and resveratrol which are effective for skin hyperpigmentation. The five components contents are 1.03, 0.2, 18.55, 6.45, and 0.48 mg/g for gallic acid, chlorogenic acid, epicatechin, rutin, and resveratrol. The kinetic study showed the tyrosinase inhibitory of RVLE via a competitive reaction mechanism. RVLE solution has an IC (the half inhibitory concentration) value of 3.84 mg/mL for tyrosinase inhibition, that is, an effective tyrosinase inhibitory activity, and can be used as a whitening agent for cosmetic formulations in the future.
天然药用植物被认为是酪氨酸酶抑制剂的良好来源。红酒叶提取物 (RVLE) 可应用于多种医学学科，例如几十年来治疗慢性静脉功能不全。本研究调查了含有没食子酸、绿原酸、表儿茶素、芦丁和白藜芦醇的 RVLE 的酪氨酸酶抑制活性，这些成分对皮肤色素沉着有效。五种成分的含量分别为没食子酸、绿原酸、表儿茶素、芦丁和白藜芦醇的 1.03、0.2、18.55、6.45 和 0.48mg/g。动力学研究表明，RVLE 通过竞争性反应机制抑制酪氨酸酶。RVLE 溶液对酪氨酸酶的 IC（半抑制浓度）值为 3.84mg/mL，具有有效的酪氨酸酶抑制活性，可在未来用作化妆品制剂的美白剂。
