Department of Physiology, Faculty of Medicine, University of Prishtina, Martyr's Boulevard n.n., Prishtina 10000, Kosovo.
Department of Biology, Faculty of Medicine, University of Prishtina, Martyr's Boulevard n.n., Prishtina 10000, Kosovo.
Can J Diabetes. 2018 Apr;42(2):179-187. doi: 10.1016/j.jcjd.2017.04.007. Epub 2017 Jun 26.
The relationship between iron and glucose metabolism has been evidenced strongly, but the molecular mediation of this connection is just being revealed. The discovery of hepcidin as the prime controller of iron metabolism has paved the way for understanding the main actors behind this mediation. Recent data suggest that insulin therapy and probably other diabetes drugs can influence hepcidin production, thus influencing the iron load in cells. Correcting iron load through hepcidin expression could be a novel and important mechanism of action of antidiabetes drugs. This effect would further establish the protective role of antidiabetes therapy and might even affect prevention strategies in diabetes. In this review, we summarize the recent data about iron-glucose links through hepcidin expression, the molecular mediation of this interplay and the clinical implications of these findings.
铁与葡萄糖代谢之间的关系已得到充分证实，但这种联系的分子中介作用才刚刚被揭示出来。作为铁代谢主要调控因子的铁调素的发现，为理解这一中介作用的主要参与者铺平了道路。最近的数据表明，胰岛素治疗和可能的其他糖尿病药物可以影响铁调素的产生，从而影响细胞内的铁负荷。通过铁调素表达来纠正铁负荷可能是抗糖尿病药物的一种新的重要作用机制。这种作用将进一步确立抗糖尿病治疗的保护作用，甚至可能影响糖尿病的预防策略。在这篇综述中，我们总结了最近关于铁-葡萄糖通过铁调素表达的联系、这种相互作用的分子中介以及这些发现的临床意义的相关数据。
