羟丙基甲基纤维素邻苯二甲酸酯包衣对绿茶儿茶素消化稳定性及肠道转运的影响
Effect of hydroxypropyl methyl cellulose phthalate coating on digestive stability and intestinal transport of green tea catechins.
作者信息
Chung Jae-Hwan, Lee Sang-Jun, Chung Jin-Oh, Oh Yu-Jin, Hwang Jeong-Ah, Kim Young-Kyung, Ko Sanghoon, Shim Soon-Mi
机构信息
Department of Food Science and Technology and Carbohydrate Bioproduct Research Center, Sejong University, Seoul, Korea.
Health Science Research Institute, AmorePacific R&D Center, Yongin, Korea.
出版信息
Integr Med Res. 2014 Mar;3(1):34-37. doi: 10.1016/j.imr.2013.11.001. Epub 2013 Dec 9.
BACKGROUND
The purpose of this study was to investigate the effect of hydroxypropyl methyl cellulose phthalate (HPMCP) coating on the digestive stability and intestinal transport of green tea catechins (GTCs).
METHODS
Two types of HPMCP coating were prepared: one type with size smaller than 500 μm (S-HPMCP) and the other with size larger than 500 μm (L-HPMCP). An gastrointestinal model system coupled with Caco-2 cells was used for estimating the bioavailability of GTCs. Ultraperformance liquid chromatography with a photodiode array detector was performed to analyze GTCs.
RESULTS
The digestive stability of GTCs was enhanced up to 33.73% and 35.28% for S-HPMCP and L-HPMCP, respectively. Intestinal transport of the GTCs was increased to 22.98% and 23.23% for S-HPMCP and L-HPMCP, respectively. Overall, the bioavailability of GTCs increased by 4.08 and 11.71 times for S-HPMCP and L-HPMCP, respectively.
CONCLUSION
The results of this study confirm that coating with HPMCP could be a way to improve the digestive stability and intestinal transport of GTCs.
背景
本研究旨在探讨邻苯二甲酸羟丙基甲基纤维素（HPMCP）包衣对绿茶儿茶素（GTCs）消化稳定性和肠道转运的影响。
方法
制备了两种类型的HPMCP包衣：一种粒径小于500μm（S-HPMCP），另一种粒径大于500μm（L-HPMCP）。采用结合Caco-2细胞的胃肠模型系统评估GTCs的生物利用度。使用配备光电二极管阵列检测器的超高效液相色谱法分析GTCs。
结果
S-HPMCP和L-HPMCP对GTCs消化稳定性的提高分别高达33.73%和35.28%。S-HPMCP和L-HPMCP使GTCs的肠道转运分别增加到22.98%和23.23%。总体而言，S-HPMCP和L-HPMCP使GTCs的生物利用度分别提高了4.08倍和11.71倍。
结论
本研究结果证实，用HPMCP包衣可能是提高GTCs消化稳定性和肠道转运的一种方法。
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