Grgić Josipa, Šelo Gordana, Planinić Mirela, Tišma Marina, Bucić-Kojić Ana
Faculty of Food Technology Osijek, Josip Juraj Strossmayer University of Osijek, F. Kuhača 18, HR-31 000 Osijek, Croatia.
Antioxidants (Basel). 2020 Sep 26;9(10):923. doi: 10.3390/antiox9100923.
Plant-derived phenolic compounds have multiple positive health effects for humans attributed to their antioxidative, anti-inflammatory, and antitumor properties, etc. These effects strongly depend on their bioavailability in the organism. Bioaccessibility, and consequently bioavailability of phenolic compounds significantly depend on the structure and form in which they are introduced into the organism, e.g., through a complex food matrix or as purified isolates. Furthermore, phenolic compounds interact with other macromolecules (proteins, lipids, dietary fibers, polysaccharides) in food or during digestion, which significantly influences their bioaccessibility in the organism, but due to the complexity of the mechanisms through which phenolic compounds act in the organism this area has still not been examined sufficiently. Simulated gastrointestinal digestion is one of the commonly used in vitro test for the assessment of phenolic compounds bioaccessibility. Encapsulation is a method that can positively affect bioaccessibility and bioavailability as it ensures the coating of the active component and its targeted delivery to a specific part of the digestive tract and controlled release. This comprehensive review aims to present the role of encapsulation in bioavailability of phenolic compounds as well as recent advances in coating materials used in encapsulation processes. The review is based on 258 recent literature references.
植物源酚类化合物因其抗氧化、抗炎和抗肿瘤等特性，对人类健康有多种积极影响。这些作用很大程度上取决于它们在生物体内的生物利用度。酚类化合物的生物可及性以及随之而来的生物利用度，显著取决于它们引入生物体的结构和形式，例如通过复杂的食物基质或作为纯化的分离物。此外，酚类化合物在食物中或消化过程中会与其他大分子（蛋白质、脂质、膳食纤维、多糖）相互作用，这显著影响它们在生物体内的生物可及性，但由于酚类化合物在生物体内发挥作用的机制复杂，这一领域仍未得到充分研究。模拟胃肠道消化是评估酚类化合物生物可及性常用的体外试验之一。包封是一种可以对生物可及性和生物利用度产生积极影响的方法，因为它能确保活性成分被包裹，并将其靶向递送至消化道的特定部位并实现控释。这篇综述旨在阐述包封在酚类化合物生物利用度中的作用以及包封过程中所用包材的最新进展。该综述基于258篇近期文献。
