Al-Zaid Tariq, Wang Wei-Lien, Somaiah Neeta, Lazar Alexander J
Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Boulevard-Unit 85, Houston, TX, 77030-4009, USA.
Virchows Arch. 2017 Aug;471(2):243-255. doi: 10.1007/s00428-017-2174-3. Epub 2017 Jun 29.
Sarcoma is a large and heterogeneous group of malignant mesenchymal neoplasms with significant histological overlap. Accurate diagnosis can be challenging yet important for selecting the appropriate treatment approach and prognosis. The currently torrid pace of new genomic discoveries aids our classification and diagnosis of sarcomas, understanding of pathogenesis, development of new medications, and identification of alterations that predict prognosis and response to therapy. Unfortunately, demonstrating effective targets for precision oncology has been elusive in most sarcoma types. The list of potential targets greatly outnumbers the list of available inhibitors at the present time. This review will discuss the role of molecular profiling in sarcomas in general with emphasis on selected entities with particular clinical relevance.
肉瘤是一大类异质性的恶性间叶组织肿瘤，在组织学上有显著重叠。准确诊断具有挑战性，但对于选择合适的治疗方法和判断预后很重要。当前新的基因组发现的迅猛发展有助于我们对肉瘤进行分类和诊断，理解其发病机制，开发新药物，以及识别可预测预后和治疗反应的改变。不幸的是，在大多数肉瘤类型中，找到精准肿瘤学的有效靶点一直难以实现。目前潜在靶点的数量远远超过了可用抑制剂的数量。本综述将总体讨论分子谱分析在肉瘤中的作用，重点关注具有特殊临床相关性的特定实体。
