Department of Medicine, University of the West Indies, Kingston 7, Jamaica.
Int J Dermatol. 2017 Aug;56(8):828-832. doi: 10.1111/ijd.13678. Epub 2017 Jun 30.
Acne keloidalis nuchae (AKN) is a chronic scarring folliculitis which usually occurs in young adult males of African descent. Studies have suggested that AKN may be associated with other dermatologic conditions and even general medical disorders. The aim of this study was to identify cutaneous and extracutaneous associated disorders and to examine risk factors in our population for developing AKN.
The study was a retrospective, descriptive, and analytical study conducted at the Dermatology Outpatient department of the University Hospital of the West Indies. Data were obtained from the medical records of patients diagnosed over a 15-year period (2000-2014).
There were 1031 new patients during the study period. Of these, 43 (4.2%) had AKN. The male to female ratio for AKN was approximately 7:1. Pseudofolliculitis barbae was associated with keloidal plaques on the scalp (OR = 6.22, P = 0.036). Also, when the duration of AKN was divided into two groups (0-5 years and greater than 5 years), there was an association between keloidal plaques and duration of greater than 5 years (OR = 7.5, P = 0.032). However, when the odds ratio was adjusted, only the duration of AKN remained significantly associated with keloidal plaques (OR = 7.08, P = 0.047). Chronic scalp folliculitis (P = 0.001) and the presence of any component disease of the metabolic syndrome (OR = 14, P = 0.008) and specifically hypertension (OR = 6.75, P = 0.036) were significantly associated with the extension of the lesions beyond the nape and occipital scalp.
Pseudofolliculitis barbae, chronic scalp folliculitis, and aspects of the metabolic syndrome may be associated with acne keloidalis nuchae.
瘢痕性脱发（AKN）是一种慢性瘢痕性毛囊炎，通常发生在非洲裔年轻成年男性中。研究表明，AKN 可能与其他皮肤疾病甚至一般医学疾病有关。本研究旨在确定我们人群中与 AKN 相关的皮肤和皮肤外相关疾病，并研究其发病的危险因素。
该研究是在西印度群岛大学医院皮肤科门诊进行的回顾性、描述性和分析性研究。数据来自于在 15 年期间（2000-2014 年）诊断的患者的病历。
在研究期间，共有 1031 名新患者。其中，43 名（4.2%）患有 AKN。AKN 的男女比例约为 7:1。假性须部毛囊角化病与头皮上的瘢痕疙瘩有关（OR=6.22，P=0.036）。此外，当 AKN 的持续时间分为两组（0-5 年和大于 5 年）时，瘢痕疙瘩与大于 5 年的持续时间之间存在关联（OR=7.5，P=0.032）。然而，当调整优势比时，只有 AKN 的持续时间与瘢痕疙瘩显著相关（OR=7.08，P=0.047）。慢性头皮滤泡炎（P=0.001）和代谢综合征的任何成分疾病的存在（OR=14，P=0.008）以及高血压（OR=6.75，P=0.036）与病变超出颈背和枕部头皮的延伸显著相关。
假性须部毛囊角化病、慢性头皮滤泡炎和代谢综合征的某些方面可能与瘢痕性脱发有关。
