Anatolieva Boyana, Kirov Veselin, Ganeva Silvia
Dermatology, Medical University, Pleven, BGR.
Dermatooncology, University Hospital, Pleven, BGR.
Cureus. 2024 Apr 27;16(4):e59119. doi: 10.7759/cureus.59119. eCollection 2024 Apr.
Acne keloidalis nuchae (AKN) is a rare dermatological condition primarily observed in men of African descent. We present a remarkable case of AKN in a 38-year-old Caucasian non-Hispanic woman with metabolic syndrome and autoimmune thyroiditis. After appropriate treatment during the one-year follow-up (including oral antibiotics, insulin sensitizers, levothyroxine, spironolactone and liraglutide), the patient demonstrated a visible reduction in plaque size and improvement of overall symptoms. Importantly, this improvement persisted even in the absence of topical treatment, further supporting the notion that hormonal abnormalities may play a significant role in the pathogenesis of AKN. This case report highlights the potential link between AKN and endocrinologic disorders, such as metabolic syndrome and autoimmune thyroiditis. However, further research is warranted to elucidate the underlying mechanisms and establish the causative relationship. Early recognition, appropriate management of associated conditions, and tailored treatment strategies may lead to better outcomes and improved quality of life.
瘢痕疙瘩性痤疮（AKN）是一种罕见的皮肤病，主要见于非洲裔男性。我们报告了一例38岁患有代谢综合征和自身免疫性甲状腺炎的非西班牙裔白种女性的显著AKN病例。在为期一年的随访期间进行适当治疗（包括口服抗生素、胰岛素增敏剂、左甲状腺素、螺内酯和利拉鲁肽）后，患者的斑块大小明显减小，总体症状有所改善。重要的是，即使在没有局部治疗的情况下，这种改善仍然持续，这进一步支持了激素异常可能在AKN发病机制中起重要作用的观点。本病例报告强调了AKN与内分泌紊乱（如代谢综合征和自身免疫性甲状腺炎）之间的潜在联系。然而，有必要进行进一步研究以阐明潜在机制并确立因果关系。早期识别、对相关病症的适当管理以及量身定制的治疗策略可能会带来更好的结果并改善生活质量。
