State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases and Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute, Sichuan Agricultural University at Wenjiang, Chengdu, Sichuan 611130, China.
Department of Plant Pathology, University of California, Davis, Davis, CA 95616, USA; Joint Bioenergy Institute, Emeryville, CA 94608, USA.
Cell. 2017 Jun 29;170(1):114-126.e15. doi: 10.1016/j.cell.2017.06.008.
Rice feeds half the world's population, and rice blast is often a destructive disease that results in significant crop loss. Non-race-specific resistance has been more effective in controlling crop diseases than race-specific resistance because of its broad spectrum and durability. Through a genome-wide association study, we report the identification of a natural allele of a CH-type transcription factor in rice that confers non-race-specific resistance to blast. A survey of 3,000 sequenced rice genomes reveals that this allele exists in 10% of rice, suggesting that this favorable trait has been selected through breeding. This allele causes a single nucleotide change in the promoter of the bsr-d1 gene, which results in reduced expression of the gene through the binding of the repressive MYB transcription factor and, consequently, an inhibition of HO degradation and enhanced disease resistance. Our discovery highlights this novel allele as a strategy for breeding durable resistance in rice.
水稻养活了世界上一半的人口，而稻瘟病是一种破坏性很强的疾病，会导致严重的作物减产。与专化抗性相比，非专化抗性在控制作物病害方面更为有效，因为它具有广谱性和持久性。通过全基因组关联研究，我们报告了在水稻中鉴定出一个 CH 型转录因子的天然等位基因，该基因赋予了稻瘟病的非专化抗性。对 3000 个测序水稻基因组的调查显示，该等位基因存在于 10%的水稻中，这表明这个有利性状是通过选育选择出来的。该等位基因导致 bsr-d1 基因启动子中的单个核苷酸发生变化，通过抑制 MYB 转录因子的结合，导致该基因表达减少，从而抑制 HO 的降解并增强抗病性。我们的发现突出了这个新的等位基因作为在水稻中培育持久抗性的一种策略。
