Iqbal Muneeb, Rahman Md Saidur, Zafar Salman, Chen Xin-Lin, Liu Jian-Xin, Liu Yong
Institute of Neurobiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, 76 West Yanta Road, Xi'an 710061, China.
University Institute of Physical Therapy, University of Lahore, 1 km Defence road, Lahore, Pakistan.
Epilepsy Behav. 2017 Aug;73:256-267. doi: 10.1016/j.yebeh.2017.06.007. Epub 2017 Jun 27.
To conduct a systematic review and meta-analysis of studies testing exercise in animal models of pilocarpine induced status epilepticus (SE) and to compare the efficacy of different training strategies used in those studies.
We searched 2 online databases (Pubmed and Web of Science) for studies analyzing the efficacy of different trainings in pilocarpine-induced SE models. Training was categorized into forced physical training (PT), voluntary PT and resistance PT. Two reviewers independently extracted data on study quality, behavioral seizures, and histological, chemical and cognitive outcomes. Data were pooled by means of a meta-analysis.
Among 17 selected studies; 174 animals from 8 studies with 10 comparison groups showed that exercise intervention after induction of SE significantly decreased spontaneous recurrent seizures with [mean difference (MD)=-1.80, 95% confidence interval (CI): -3.22, -0.37, p=0.02] and 60 animals showed statistically significant decrease in latency in Morris water maze (standardized mean difference (SMD)=-2.57, 95% CI: -4.06, -1.08, p=0.0007). Although not statistically significant, still a remarkable increase in number of CA1 neurons and hippocampal BDNF level (MD=2.27, [95% CI: -1.20, 5.73], p=0.19, SMD=1.07, [95% CI: -0.36, 2.51], p=0.14 respectively) and a decrease in mossy fibers sprouting (SMD=-1.03, [95% CI: -3.06, 1.00], p=0.32) were observed. PT interventions in 72 animals before induction of SE showed favorable increase in latency to develop SE (MD=8.34, [95% CI: -3.10, 19.78], p=0.15) but no remarkable improvements in latency for the first motor sign and motor signs intensity.
PT after SE reduces the recurrent seizures and improves the morphological, biochemical and cognitive profiles of pilocarpine epileptic models. Resistance PT was identified as particularly effective in reducing behavioral seizures. The efficacy of training was also dependent upon duration.
对毛果芸香碱诱导的癫痫持续状态（SE）动物模型中运动测试的研究进行系统评价和荟萃分析，并比较这些研究中使用的不同训练策略的疗效。
我们在两个在线数据库（PubMed和科学网）中搜索分析不同训练对毛果芸香碱诱导的SE模型疗效的研究。训练分为强迫体育训练（PT）、自愿PT和抗阻PT。两名评审员独立提取关于研究质量、行为性癫痫发作以及组织学、化学和认知结果的数据。通过荟萃分析汇总数据。
在17项选定研究中；来自8项研究的174只动物和10个比较组表明，SE诱导后进行运动干预可显著减少自发性复发性癫痫发作[平均差（MD）=-1.80，95%置信区间（CI）：-3.22，-0.37，p=0.02]，60只动物在莫里斯水迷宫中的潜伏期有统计学显著降低（标准化平均差（SMD）=-2.57，95%CI：-4.06，-1.08，p=0.0007）。虽然无统计学显著性，但CA1神经元数量和海马脑源性神经营养因子水平仍有显著增加（MD=2.27，[95%CI：-1.20，5.73]，p=0.19，SMD=1.07，[95%CI：-0.36，2.51]，p=0.14），苔藓纤维出芽减少（SMD=-1.03，[95%CI：-3.06，1.00]，p=0.32）。在72只动物中，SE诱导前进行PT干预显示SE发作潜伏期有良好增加（MD=8.34，[95%CI：-3.10，19.78]，p=0.15），但首次运动体征潜伏期和运动体征强度无显著改善。
SE后进行PT可减少复发性癫痫发作，并改善毛果芸香碱癫痫模型的形态学、生化和认知特征。抗阻PT被确定在减少行为性癫痫发作方面特别有效。训练效果还取决于持续时间。
