Villum Center for Bioanalytical Sciences, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark.
Villum Center for Bioanalytical Sciences, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark.
Trends Endocrinol Metab. 2017 Sep;28(9):669-683. doi: 10.1016/j.tem.2017.06.001. Epub 2017 Jun 28.
The skin is the largest sensory organ of the human body. The skin not only prevents loss of water and other components of the body, but also is involved in regulation of body temperature and serves as an essential barrier, protecting mammals from both routine and extreme environments. Given the importance of the skin in temperature regulation, it is surprising that adaptive alterations in skin functions and morphology only vaguely have been associated with systemic physiological responses. Despite that impaired lipid metabolism in the skin often impairs the epidermal permeability barrier and insulation properties of the skin, its role in regulating systemic physiology and metabolism is yet to be recognized.
皮肤是人体最大的感觉器官。皮肤不仅可以防止身体水分和其他成分的流失，还参与体温调节，是哺乳动物免受日常和极端环境影响的重要屏障。鉴于皮肤在体温调节中的重要性，令人惊讶的是，皮肤功能和形态的适应性改变与全身生理反应只有模糊的关联。尽管皮肤中脂质代谢受损常常会损害表皮的通透性屏障和皮肤的绝热性能，但它在调节全身生理和代谢中的作用尚未得到认可。
