Wu Yuelan, Liu Xiaoxue, Zhang Xiaoyu, Zhang Shuping, Niu Panhong, Gao Hua
Qingdao University Qingdao Shandong 266071 P. R. China
Eye Institute of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology Qingdao Shandong 250071 P. R. China.
RSC Adv. 2023 Jul 28;13(33):22863-22874. doi: 10.1039/d3ra03246a. eCollection 2023 Jul 26.
Drug-resistant bacteria caused by the abuse of antibiotics have brought great challenges to antimicrobial therapy. Herein an antibiotic-free polydopamine (PDA) modified metal-organic framework (PDA-FDM-23) with photothermal-enhanced chemodynamic effect was developed for synergistic antibacterial treatment. The PDA-FDM-23 antibacterial agent exhibited high peroxidase-like activity. Moreover, the process was significantly accelerated by consuming glutathione (GSH) to generate more efficient oxidizing Cu. In addition, the photothermal therapy (PTT) derived from PDA improved the chemodynamic therapy (CDT) activity triggering a reactive oxygen species explosion. This PTT-enhanced CDT strategy illustrated 100% antibacterial efficiency against both and . Cytotoxicity and hemolysis analyses fully demonstrated the excellent biocompatibility of PDA-FDM-23. Overall, our work highlighted the strong peroxidase catalytic activity, excellent GSH consumption and photothermal performance of PDA-FDM-23, providing a new strategy for antibiotic-free reactive oxygen species (ROS) synergistic sterilization.
抗生素滥用导致的耐药菌给抗菌治疗带来了巨大挑战。在此，我们开发了一种具有光热增强化学动力学效应的无抗生素聚多巴胺（PDA）修饰金属有机框架（PDA-FDM-23）用于协同抗菌治疗。PDA-FDM-23抗菌剂表现出高类过氧化物酶活性。此外，通过消耗谷胱甘肽（GSH）生成更高效的氧化性铜，该过程显著加速。此外，源自PDA的光热疗法（PTT）提高了化学动力学疗法（CDT）活性，引发活性氧爆发。这种PTT增强的CDT策略对[具体细菌1]和[具体细菌2]均显示出100%的抗菌效率。细胞毒性和溶血分析充分证明了PDA-FDM-23具有优异的生物相容性。总体而言，我们的工作突出了PDA-FDM-23强大的过氧化物酶催化活性、优异的GSH消耗和光热性能，为无抗生素的活性氧（ROS）协同杀菌提供了一种新策略。
