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胆汁酸核受体 FXRα 是调控小鼠生殖细胞命运的关键调节因子。

The Bile Acid Nuclear Receptor FXRα Is a Critical Regulator of Mouse Germ Cell Fate.

机构信息

INSERM U 1103, Université Clermont Auvergne, CNRS UMR 6293, Laboratoire GReD, 28 Place Henri Dunant, 63000 Clermont-Ferrand, France.

INSERM U 1103, Université Clermont Auvergne, CNRS UMR 6293, Laboratoire GReD, 28 Place Henri Dunant, 63000 Clermont-Ferrand, France; Centre de Recherche en Nutrition Humaine d'Auvergne, 63000 Clermont-Ferrand, France.

出版信息

Stem Cell Reports. 2017 Jul 11;9(1):315-328. doi: 10.1016/j.stemcr.2017.05.036. Epub 2017 Jun 29.

DOI:10.1016/j.stemcr.2017.05.036
PMID:28669602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5511114/
Abstract

Spermatogenesis is the process by which spermatozoa are generated from spermatogonia. This cell population is heterogeneous, with self-renewing spermatogonial stem cells (SSCs) and progenitor spermatogonia that will continue on a path of differentiation. Only SSCs have the ability to regenerate and sustain spermatogenesis. This makes the testis a good model to investigate stem cell biology. The Farnesoid X Receptor alpha (FXRα) was recently shown to be expressed in the testis. However, its global impact on germ cell homeostasis has not yet been studied. Here, using a phenotyping approach in Fxrα mice, we describe unexpected roles of FXRα on germ cell physiology independent of its effects on somatic cells. FXRα helps establish and maintain an undifferentiated germ cell pool and in turn influences male fertility. FXRα regulates the expression of several pluripotency factors. Among these, in vitro approaches show that FXRα controls the expression of the pluripotency marker Lin28 in the germ cells.

摘要

精子发生是指精子从精原细胞生成的过程。该细胞群体具有异质性，包括自我更新的精原干细胞（SSC）和祖细胞精原细胞，它们将继续分化。只有 SSC 具有再生和维持精子发生的能力。这使得睾丸成为研究干细胞生物学的良好模型。最近已经表明法尼醇 X 受体α（FXRα）在睾丸中表达。然而，其对生殖细胞动态平衡的全局影响尚未研究。在这里，我们使用 Fxrα 小鼠的表型分析方法，描述了 FXRα 对生殖细胞生理学的意外作用，而不依赖于其对体细胞的影响。FXRα 有助于建立和维持未分化的生殖细胞库，并反过来影响男性生育能力。FXRα 调节几种多能性因子的表达。在这些因子中，体外方法表明 FXRα 控制着生殖细胞中多能性标记物 Lin28 的表达。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cb7/5511114/ec06566c44fa/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cb7/5511114/82a1d6c83cac/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cb7/5511114/8ce468843bac/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cb7/5511114/d3e120318a70/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cb7/5511114/f25a18546e73/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cb7/5511114/a0e0e6fa4871/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cb7/5511114/2aef779f2204/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cb7/5511114/daccec0ed2a6/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cb7/5511114/ec06566c44fa/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cb7/5511114/82a1d6c83cac/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cb7/5511114/8ce468843bac/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cb7/5511114/d3e120318a70/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cb7/5511114/f25a18546e73/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cb7/5511114/a0e0e6fa4871/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cb7/5511114/2aef779f2204/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cb7/5511114/daccec0ed2a6/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cb7/5511114/ec06566c44fa/gr7.jpg

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