Starling Anne P, Adgate John L, Hamman Richard F, Kechris Katerina, Calafat Antonia M, Ye Xiaoyun, Dabelea Dana
Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado, USA.
Department of Environmental and Occupational Health, Colorado School of Public Health, Aurora, Colorado, USA.
Environ Health Perspect. 2017 Jun 26;125(6):067016. doi: 10.1289/EHP641.
Certain perfluoroalkyl and polyfluoroalkyl substances (PFAS) are widespread, persistent environmental contaminants. Prenatal PFAS exposure has been associated with lower birth weight; however, impacts on body composition and factors responsible for this association are unknown.
We aimed to estimate associations between maternal PFAS concentrations and offspring weight and adiposity at birth, and secondarily to estimate associations between PFAS concentrations and maternal glucose and lipids, and to evaluate the potential for these nutrients to mediate associations between PFAS and neonatal outcomes.
Within the Healthy Start prospective cohort, concentrations of 11 PFAS, fasting glucose, and lipids were measured in maternal mid-pregnancy serum (n=628). Infant body composition was measured using air displacement plethysmography. Associations between PFAS and birth weight and adiposity, and between PFAS and maternal glucose and lipids, were estimated via linear regression. Associations were decomposed into direct and indirect effects.
Five PFAS were detectable in >50% of participants. Maternal perfluorooctanoate (PFOA) and perfluorononanoate (PFNA) concentrations were inversely associated with birth weight. Adiposity at birth was approximately 10% lower in the highest categories of PFOA, PFNA, and perfluorohexane sulfonate (PFHxS) compared to the lowest categories. PFOA, PFNA, perfluorodecanoate (PFDeA), and PFHxS were inversely associated with maternal glucose. Up to 11.6% of the effect of PFAS on neonatal adiposity was mediated by maternal glucose concentrations. Perfluorooctane sulfonate (PFOS) was not significantly associated with any outcomes studied.
Follow-up of offspring will determine the potential long-term consequences of lower weight and adiposity at birth associated with prenatal PFAS exposure. https://doi.org/10.1289/EHP641.
某些全氟烷基和多氟烷基物质（PFAS）是广泛存在、持久的环境污染物。产前暴露于PFAS与较低出生体重有关；然而，对身体成分的影响以及造成这种关联的因素尚不清楚。
我们旨在估计母亲PFAS浓度与出生时后代体重和肥胖之间的关联，其次估计PFAS浓度与母亲血糖和血脂之间的关联，并评估这些营养素介导PFAS与新生儿结局之间关联的可能性。
在“健康起步”前瞻性队列研究中，测量了孕中期母亲血清中11种PFAS、空腹血糖和血脂的浓度（n = 628）。使用空气置换体积描记法测量婴儿身体成分。通过线性回归估计PFAS与出生体重和肥胖之间以及PFAS与母亲血糖和血脂之间的关联。将关联分解为直接和间接效应。
超过50%的参与者可检测到5种PFAS。母亲全氟辛酸（PFOA）和全氟壬酸（PFNA）浓度与出生体重呈负相关。与最低类别相比，PFOA、PFNA和全氟己烷磺酸（PFHxS）最高类别出生时的肥胖率低约10%。PFOA、PFNA、全氟癸酸（PFDeA）和PFHxS与母亲血糖呈负相关。PFAS对新生儿肥胖的影响中，高达11.6%由母亲血糖浓度介导。全氟辛烷磺酸（PFOS）与所研究的任何结局均无显著关联。
对后代的随访将确定产前PFAS暴露与出生时体重和肥胖降低相关的潜在长期后果。https://doi.org/10.1289/EHP641
