Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark.
Department of Endocrinology, Odense University Hospital, Odense, Denmark.
Environ Health Perspect. 2020 Jul;128(7):77001. doi: 10.1289/EHP5184. Epub 2020 Jul 6.
Perfluoroalkyl acids (PFAA) are repellants that cross the placental barrier, enabling interference with fetal programming. Maternal PFAA concentrations have been associated with offspring obesity and dyslipidemia in childhood and adulthood, but this association has not been studied in infancy.
We investigated associations between maternal PFAA concentrations and repeated markers of adiposity and lipid metabolism in infancy.
In the prospective Odense Child Cohort, maternal pregnancy serum concentrations of five PFAA: Perfluorohexane sulfonic acid (PFHxS), perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) were measured in 649 women. Offspring were examined at birth () and at 3 months () and 18 months () of age. Total cholesterol, LDL, HDL, and triglyceride were evaluated at 3 months () and 18 months () of age. Mixed effects linear regression models estimated associations between PFAA and standardized (SDS) body mass index (BMI), ponderal index, and waist circumference. Associations between PFAA and body fat% (BF%) and plasma lipids SDS at 3 months and 18 months of age were investigated with linear regression models.
PFNA and PFDA were associated with higher BMI SDS [adjusted ; 95% confidence interval (CI): 0.03, 0.49 and ; 95% CI: , 1.19, respectively, for increases] and ponderal index SDS (; 95% CI: 0.13, 0.59 and ; 95% CI: 0.40, 1.64, respectively) at 3 and 18 months of age (pooled) in girls. Corresponding estimates for boys were closer to the null but not significantly different from estimates for girls. In boys and girls (combined), PFNA and PFDA were associated with BF% at age 3 months (for PFDA, ; 95% CI: 0.04, 0.75), and PFDA was associated with total cholesterol SDS at 18 months (; 95% CI: 0.08, 2.03) ().
Prenatal PFAA were positively associated with longitudinal markers of adiposity and higher total cholesterol in infancy. These findings deserve attention in light of rising rates of childhood overweight conditions and dyslipidemia. https://doi.org/10.1289/EHP5184.
全氟烷基酸 (PFAA) 是一种驱避剂，可穿过胎盘屏障，从而干扰胎儿的编程。母体 PFAA 浓度与儿童和成年期后代肥胖和血脂异常有关，但在婴儿期尚未对此进行研究。
我们研究了母体 PFAA 浓度与婴儿期反复出现的肥胖和脂质代谢标志物之间的关联。
在前瞻性的奥登塞儿童队列中，在 649 名女性的妊娠血清中测量了五种 PFAA：全氟己烷磺酸 (PFHxS)、全氟辛烷磺酸 (PFOS)、全氟辛酸 (PFOA)、全氟壬酸 (PFNA) 和全氟癸酸 (PFDA)。在婴儿出生时 ()、3 个月 () 和 18 个月 () 时对婴儿进行检查。在 3 个月 () 和 18 个月 () 时评估总胆固醇、LDL、HDL 和甘油三酯。使用线性回归模型研究了 PFAA 与标准化 (SDS) 体重指数 (BMI)、体脂指数和腰围之间的关系。使用线性回归模型研究了 PFAA 与 3 个月和 18 个月时体脂肪百分比 (BF%) 和血浆脂质 SDS 的关系。
在女孩中，PFNA 和 PFDA 与 3 个月和 18 个月时 BMI SDS [调整后 ; 95%置信区间 (CI)：0.03，0.49 和 ; 95%CI： ，1.19，分别， 增加]和体脂指数 SDS (; 95%CI：0.13，0.59 和 ; 95%CI：0.40，1.64，分别)呈正相关。对于男孩，相应的估计值更接近零，但与女孩的估计值没有显著差异。在男孩和女孩 (合并)中，PFNA 和 PFDA 与 3 个月时的 BF% 呈正相关 (对于 ， ; 95%CI：0.04，0.75)，并且 PFDA 与 18 个月时的总胆固醇 SDS 呈正相关 ( ; 95%CI：0.08，2.03) ( )。
产前 PFAA 与婴儿期肥胖的纵向标志物和总胆固醇升高呈正相关。鉴于儿童超重和血脂异常的发病率不断上升，这些发现值得关注。https://doi.org/10.1289/EHP5184.
