台湾母婴队列研究中孕期全氟羧酸（PFCA）暴露与胎儿及产后生长情况
Prenatal Exposure to Perfluorocarboxylic Acids (PFCAs) and Fetal and Postnatal Growth in the Taiwan Maternal and Infant Cohort Study.
作者信息
Wang Yan, Adgent Margaret, Su Pen-Hua, Chen Hsiao-Yen, Chen Pau-Chung, Hsiung Chao A, Wang Shu-Li
机构信息
National Foundation for the Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
出版信息
Environ Health Perspect. 2016 Nov;124(11):1794-1800. doi: 10.1289/ehp.1509998. Epub 2016 Feb 19.
BACKGROUND
Perfluorocarboxylic acids (PFCAs) are environmentally and biologically persistent synthetic chemicals. PFCAs include perfluorooctanoic acid (PFOA; C8) and long-chain PFCAs (C9-C20). Studies examining long-chain PFCAs and fetal and postnatal growth are limited.
OBJECTIVES
We investigated the associations of prenatal exposure to long-chain PFCAs with fetal and postnatal growth.
METHODS
For 223 Taiwanese mothers and their term infants, we measured PFOA and four long-chain PFCAs (ng/mL) in third-trimester maternal serum; infant weight (kg), length and head circumference (cm) at birth; and childhood weight and height at approximately 2, 5, 8, and 11 years of age. For each sex, we used multivariable linear regression to examine associations between ln-transformed prenatal PFCAs and continuous infant measures, and logistic regression to examine small for gestational age (SGA). Linear mixed models were applied to prenatal PFCAs and childhood weight and height z-scores.
RESULTS
In girls, prenatal perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDeA), perfluoroundecanoic acid (PFUnDA), and perfluorododecanoic acid (PFDoDA) concentrations were inversely associated with birth weight [e.g., βbirth weight (kg) = -0.06, 95% CI: -0.11, -0.01 per 1 ln-unit PFUnDA increase]; prenatal PFDeA and PFUnDA were associated with elevated odds of SGA; and PFDeA, PFUnDA, and PFDoDA were associated with lower average childhood height z-score. In boys, prenatal PFNA, and PFDoDA were associated with reductions in height at certain ages in childhood, but not with size at birth.
CONCLUSIONS
Prenatal exposure to long-chain PFCAs may interfere with fetal and childhood growth in girls, and childhood growth in boys. Citation: Wang Y, Adgent M, Su PH, Chen HY, Chen PC, Hsiung CA, Wang SL. 2016. Prenatal exposure to perfluorocarboxylic acids (PFCAs) and fetal and postnatal growth in the Taiwan Maternal and Infant Cohort Study. Environ Health Perspect 124:1794-1800; http://dx.doi.org/10.1289/ehp.1509998.
背景
全氟羧酸（PFCA）是环境和生物持久性合成化学品。全氟羧酸包括全氟辛酸（PFOA；C8）和长链全氟羧酸（C9 - C20）。关于长链全氟羧酸与胎儿及产后生长的研究有限。
目的
我们调查了产前暴露于长链全氟羧酸与胎儿及产后生长之间的关联。
方法
对于223名台湾母亲及其足月婴儿，我们测量了孕晚期母亲血清中的全氟辛酸和四种长链全氟羧酸（纳克/毫升）；婴儿出生时的体重（千克）、身长和头围（厘米）；以及大约2、5、8和11岁时儿童期的体重和身高。对于每种性别，我们使用多变量线性回归来研究经自然对数转换的产前全氟羧酸与婴儿连续测量指标之间的关联，并使用逻辑回归来研究小于胎龄儿（SGA）。将线性混合模型应用于产前全氟羧酸与儿童期体重和身高z评分。
结果
在女孩中，产前全氟壬酸（PFNA）、全氟癸酸（PFDeA）、全氟十一烷酸（PFUnDA）和全氟十二烷酸（PFDoDA）浓度与出生体重呈负相关[例如，每增加1个自然对数单位的PFUnDA，出生体重（千克）的β值 = -0.06，95%可信区间：-0.11，-0.01]；产前PFDeA和PFUnDA与小于胎龄儿的几率升高有关；PFDeA、PFUnDA和PFDoDA与儿童期平均身高z评分较低有关。在男孩中，产前PFNA和PFDoDA与儿童期特定年龄的身高降低有关，但与出生时的大小无关。
结论
产前暴露于长链全氟羧酸可能会干扰女孩的胎儿期和儿童期生长以及男孩的儿童期生长。引文：Wang Y, Adgent M, Su PH, Chen HY, Chen PC, Hsiung CA, Wang SL. 2016. Prenatal exposure to perfluorocarboxylic acids (PFCAs) and fetal and postnatal growth in the Taiwan Maternal and Infant Cohort Study. Environ Health Perspect 124:1794 - 1800; http://dx.doi.org/10.1289/ehp.1509998.
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