Yeboah Francis Agyemang, Ngala Robert Amadu, Bawah Ahmed Tijani, Asare-Anane Henry, Alidu Huseini, Hamid Abdul-Wahab Mawuko, Wumbee Joshua Dokurugu Kwame
Department of Molecular Medicine, Kwame Nkrumah University of Science and Technology, Kumasi.
Department of Medical Laboratory Science, University of Health and Allied Sciences, Ho.
Int J Womens Health. 2017 Jun 16;9:449-454. doi: 10.2147/IJWH.S134088. eCollection 2017.
Leptin levels start increasing from the early stages of pregnancy, irrespective of the maternal body mass index. Leptin levels are increased in pregnant women with preeclampsia (PE) and may precede the clinical onset of the disease, with peaks occurring around 28 weeks of gestation. This study was aimed at determining whether serum leptin concentration and body fat percentage are significantly altered during the first trimester in pregnancies that subsequently develop PE and whether such changes are useful in predicting the disease.
This was a prospective longitudinal study conducted among pregnant women in Ho municipality. A cohort of 314 pregnant women was monitored from the first antenatal visit to delivery period at the Volta Regional Hospital, Ho, Ghana. Maternal serum leptin and lipid profile were analyzed and body fat percentage determined during first trimester. Body mass index was also calculated.
First trimester serum leptin level (<0.0001) and body fat percentage (<0.0001) were significantly higher in those who developed PE than those who did not; while triglycerides (=0.8600), total cholesterol (=0.5620), high-density lipoprotein (=0.5880), low-density lipoprotein (=0.4870) and very low-density lipoprotein (=0.6540) did not show any significant difference between those with PE and those without PE.
Leptin levels are increased significantly during the first trimester of pregnancy in obese women with PE, and these increases precede the onset of PE.
无论孕妇体重指数如何，瘦素水平从妊娠早期开始升高。子痫前期（PE）孕妇的瘦素水平升高，且可能在疾病临床发作之前出现，在妊娠约28周时达到峰值。本研究旨在确定随后发生PE的妊娠早期血清瘦素浓度和体脂百分比是否有显著变化，以及这些变化是否有助于预测该疾病。
这是一项在霍市对孕妇进行的前瞻性纵向研究。在加纳霍的沃尔特地区医院，对314名孕妇从首次产前检查到分娩期间进行了监测。分析了孕妇血清瘦素和血脂谱，并在孕早期测定了体脂百分比。还计算了体重指数。
发生PE的孕妇孕早期血清瘦素水平（<0.0001）和体脂百分比（<0.0001）显著高于未发生PE的孕妇；而甘油三酯（=0.8600）、总胆固醇（=0.5620）、高密度脂蛋白（=0.5880）、低密度脂蛋白（=0.4870）和极低密度脂蛋白（=0.6540）在发生PE和未发生PE的孕妇之间没有显示出任何显著差异。
患有PE的肥胖孕妇在妊娠早期瘦素水平显著升高，且这些升高在PE发作之前出现。
