伊朗患者群体中浸润性乳腺癌中人巨细胞病毒抗原表达的评估。
Evaluation of human cytomegalovirus antigen expression in invasive breast carcinoma in a population of Iranian patients.
作者信息
Mohammadizadeh Fereshteh, Mahmudi Fatemeh
机构信息
Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Infect Agent Cancer. 2017 Jun 26;12:39. doi: 10.1186/s13027-017-0148-3. eCollection 2017.
BACKGROUND
The role of human cytomegalovirus (HCMV) in the development of breast carcinoma is questionable. The aim of this study was to evaluate the expression of the immediate early antigen (IE) of HCMV in breast carcinoma and its association with some clinicopathologic factors in a population of Iranian patients.
METHODS
Formalin-fixed and paraffin-embedded tissue blocks from the pathology laboratories of the Azahra and Shahid Beheshti hospitals, Isfahan, Iran, from 2013 to 2016, were used in the study. We used immunohistochemistry and real-time PCR to detect the IE-antigen of HCMV in breast carcinoma, normal tissue adjacent to carcinoma, and normal tissue from mammoplasty specimens.
RESULTS
A total of 96 samples were evaluated: 70 invasive breast carcinoma of different histologic subtypes and 26 mammoplasty normal breast tissues. All the samples were negative for IE-antigen expression. No relationship was seen between breast cancer and HCMV in this study.
CONCLUSIONS
The results of this study failed to show any relationship between HCMV and the development of breast carcinoma.
背景
人巨细胞病毒（HCMV）在乳腺癌发生发展中的作用存在疑问。本研究旨在评估HCMV即刻早期抗原（IE）在伊朗患者人群乳腺癌中的表达及其与一些临床病理因素的关联。
方法
研究使用了2013年至2016年来自伊朗伊斯法罕阿扎赫拉医院和沙希德·贝赫什提医院病理实验室的福尔马林固定石蜡包埋组织块。我们采用免疫组织化学和实时聚合酶链反应检测乳腺癌、癌旁正常组织及隆乳术标本正常组织中HCMV的IE抗原。
结果
共评估96个样本：70例不同组织学亚型的浸润性乳腺癌和26例隆乳术正常乳腺组织。所有样本的IE抗原表达均为阴性。本研究未发现乳腺癌与HCMV之间存在关联。
结论
本研究结果未显示HCMV与乳腺癌发生之间存在任何关联。
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