具有RAM免疫表型的急性髓系白血病：一例具有不寻常形态学特征的儿科病例。
Acute Myeloid Leukemia with RAM Immunophenotype: A Pediatric Case with Unusual Morphologic Features.
作者信息
Conces Miriam, Abu-Arja Rolla, Reed Suzanne, Rangarajan Hemalatha G, Guinipero Terri L, Loken Michael R, Brodersen Lisa Eidenschink, Kahwash Samir B
机构信息
Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
Division of Hematology/Oncology and Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, OH, USA.
出版信息
Hematol Rep. 2017 Jun 14;9(2):7057. doi: 10.4081/hr.2017.7057. eCollection 2017 Jun 1.
The RAM immunophenotype has been recently described as a subtype of acute myelogenous leukemia (AML) that is characterized clinically by extremely poor prognosis. We present a case of AML with RAM immunophenotype in a 5-year-old patient that resulted in poor outcome despite early hematopoietic cell transplant. We describe the unusual morphologic features that, along with the distinct immunophenotype, may provide initial diagnostic clues and further justify the classification of this AML variant as a rather distinct subtype.
RAM免疫表型最近被描述为急性髓系白血病（AML）的一种亚型，其临床特征是预后极差。我们报告了一例5岁患有RAM免疫表型的AML患者，尽管早期进行了造血细胞移植，但结果仍不理想。我们描述了其不寻常的形态学特征，这些特征与独特的免疫表型一起，可能提供初步诊断线索，并进一步证明将这种AML变异型归类为一个相当独特的亚型是合理的。
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