Raliya Ramesh, Som Avik, Shetty Nishit, Reed Nathan, Achilefu Samuel, Biswas Pratim
Department of Energy, Environmental and Chemical Engineering, Washington University, St. Louis, Missouri, 63130 USA.
Departments of Biomedical Engineering, Washington University School of Medicine, St. Louis, Missouri, 63110, USA.
RSC Adv. 2016;6(59):54331-54335. doi: 10.1039/c6ra12856d. Epub 2016 Jun 1.
Antacids are crucial in the treatment of gastro-esophageal reflux disease and peptic ulcers. Antacids based on the calcite phase of bulk calcium carbonate have been the standard for over fifty years. More recent research has shown that nanomaterial forms of such bulk materials often have improved properties. However, the metastable vaterite form of calcium carbonate is particularly difficult to synthesize as a nanomaterial, and thus has not been extensively studied. Here, we describe the synthesis of these particles and investigate them for antacid applications. Experimental and computational approaches show that nanoscale vaterite particles maintain neutral gastric pH values three times longer than commercial antacids.
抗酸剂在胃食管反流病和消化性溃疡的治疗中至关重要。基于块状碳酸钙方解石相的抗酸剂五十多年来一直是标准药物。最近的研究表明，此类块状材料的纳米材料形式通常具有更好的性能。然而，碳酸钙的亚稳态球霰石形式作为纳米材料特别难以合成，因此尚未得到广泛研究。在此，我们描述了这些颗粒的合成，并研究了它们在抗酸应用中的性能。实验和计算方法表明，纳米级球霰石颗粒维持胃内中性pH值的时间是市售抗酸剂的三倍。
