McGreevy Cora, Barry Miriam, Davenport Colin, Byrne Brendan, Donaghy Caroline, Collier Geraldine, Tormey William, Smith Diarmuid, Bennett Kathleen, Williams David
Department of Stroke and Geriatric Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.
Department of Stroke and Geriatric Medicine, Beaumont Hospital, Dublin, Ireland.
J Am Soc Hypertens. 2015 Mar;9(3):176-83. doi: 10.1016/j.jash.2014.12.019. Epub 2014 Dec 31.
Vitamin D deficiency may lead to impaired vascular function and abnormalities in central arterial stiffness. We compared the effects of two different doses of vitamin D3 on arterial stiffness in an elderly population with deficient serum 25-hydroxy-vitamin D levels. A total of 119 known vitamin D deficient (<50 nmol/L) subjects were randomized to receive either 50,000 international units (IU) or 100,000 IU single intramuscular vitamin D3. In the group that received 100,000 IU vitamin D, median pulse wave velocity decreased from 12.2 m/s (range, 5.1-40.3 m/s) to 11.59 m/s (range, 4.3-14.9 m/s) after 8 weeks (P = .22). A mean decrease of 3.803 ± 1.7 (P = .032) in augmentation index (a measure of systemic stiffness) was noted. Only 3/51 (5.8%) who received 100,000 IU vitamin D reached levels of sufficiency (>75 nmol/L). A significant decrease in augmentation index was seen in the group that received 100,000 IU vitamin D. Serum levels of 25-hydroxy-vitamin D were still deficient at 8 weeks in the majority of patients, which may be attributable to impaired bioavailability.
维生素D缺乏可能导致血管功能受损和中心动脉僵硬度异常。我们比较了两种不同剂量的维生素D3对血清25-羟基维生素D水平缺乏的老年人群动脉僵硬度的影响。共有119名已知维生素D缺乏（<50 nmol/L）的受试者被随机分配接受单次肌内注射50,000国际单位（IU）或100,000 IU的维生素D3。在接受100,000 IU维生素D的组中，8周后脉搏波速度中位数从12.2米/秒（范围5.1 - 40.3米/秒）降至11.59米/秒（范围4.3 - 14.9米/秒）（P = 0.22）。发现增强指数（全身僵硬度的一种测量指标）平均下降了3.803±1.7（P = 0.032）。接受100,000 IU维生素D的患者中只有3/51（5.8%）达到了充足水平（>75 nmol/L）。接受100,000 IU维生素D的组中增强指数有显著下降。大多数患者在8周时血清25-羟基维生素D水平仍缺乏，这可能归因于生物利用度受损。
