一项关于补充维生素D对美国原住民女性动脉僵硬度和主动脉血压影响的随机对照试验。
A randomized controlled trial of the effects of vitamin D supplementation on arterial stiffness and aortic blood pressure in Native American women.
作者信息
Gepner Adam D, Haller Irina V, Krueger Diane C, Korcarz Claudia E, Binkley Neil, Stein James H
机构信息
University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Essentia Institute of Rural Health, Duluth, MN, USA.
出版信息
Atherosclerosis. 2015 Jun;240(2):526-8. doi: 10.1016/j.atherosclerosis.2015.04.795. Epub 2015 Apr 25.
OBJECTIVE
It is unclear if vitamin D supplementation improves central blood pressure or arterial stiffness in Native American (NA) women.
METHODS
Healthy postmenopausal NA women were randomized to receive 400 IU or 2500 IU of vitamin D for 6 months. Central systolic blood pressure (cSBP), central pulse pressure (cPP) and aortic augmentation index (AIx) were estimated by tonometry at baseline and after 6 months.
RESULTS
Study volunteers (n = 98) were 61 (7.3) years old. 25(OH)D was 26.4 (11.0) ng/mL. 25(OH)D was similar between the two treatment groups (p = 0.291), as were baseline cSBP, cPP, and CVD risk factors (all p > 0.1). Treatment with 2500 IU of daily vitamin D3 did not affect cSBP, cPP, or AIx (all p > 0.1) compared to 400 IU daily.
CONCLUSIONS
Despite low serum 25(OH)D at baseline, 6 months of vitamin D supplementation did not improve central blood pressure parameters or arterial stiffness in NA women. CLINICAL TRIALS.
GOV IDENTIFIER
NCT01490333.
目的
尚不清楚补充维生素D是否能改善美国原住民（NA）女性的中心血压或动脉僵硬度。
方法
将健康的绝经后NA女性随机分为两组，分别接受400 IU或2500 IU维生素D治疗6个月。在基线和6个月后通过眼压测量法估算中心收缩压（cSBP）、中心脉压（cPP）和主动脉增强指数（AIx）。
结果
研究志愿者（n = 98）年龄为61（7.3）岁。25（OH）D为26.4（11.0）ng/mL。两个治疗组之间的25（OH）D相似（p = 0.291），基线cSBP、cPP和心血管疾病风险因素也相似（所有p>0.1）。与每日400 IU相比，每日2500 IU维生素D3治疗对cSBP、cPP或AIx均无影响（所有p>0.1）。
结论
尽管基线时血清25（OH）D水平较低，但补充6个月维生素D并未改善NA女性的中心血压参数或动脉僵硬度。临床试验。
政府标识符
NCT01490333。
Zotero 插件