Zafarani Hamid Reza, Mathwig Klaus, Sudhölter Ernst J R, Rassaei Liza
Laboratory of Organic Materials and Interfaces, Department of Chemical Engineering, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands.
University of Groningen, Groningen Research Institute of Pharmacy, Pharmaceutical Analysis, P.O. Box 196, 9700 AD Groningen, The Netherlands.
ACS Sens. 2017 Jun 23;2(6):724-728. doi: 10.1021/acssensors.7b00180. Epub 2017 May 16.
We report a strategy for the fabrication of a new type of electrochemical nanogap transducer. These nanogap devices are based on signal amplification by redox cycling. Using two steps of electron-beam lithography, vertical gold electrodes are fabricated side by side at a 70 nm distance encompassing a 20 attoliter open nanogap volume. We demonstrate a current amplification factor of 2.5 as well as the possibility to detect the signal of only 60 analyte molecules occupying the detection volume. Experimental voltammetry results are compared to calculations from finite element analysis.
我们报告了一种用于制造新型电化学纳米间隙传感器的策略。这些纳米间隙器件基于氧化还原循环进行信号放大。通过两步电子束光刻，在相距70纳米的位置并排制造垂直金电极，形成一个20阿托升的开放纳米间隙体积。我们展示了2.5的电流放大倍数以及检测仅占据检测体积的60个分析物分子信号的可能性。将实验伏安法结果与有限元分析的计算结果进行了比较。
