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用于在抗坏血酸存在下通过电化学技术测定尿酸的普鲁士蓝修饰电极的研制。

Development of a PrGO-Modified Electrode for Uric Acid Determination in the Presence of Ascorbic Acid by an Electrochemical Technique.

作者信息

Tukimin Nurulkhalilah, Abdullah Jaafar, Sulaiman Yusran

机构信息

Department of Chemistry, Faculty of Science, Universiti Putra Malaysia (UPM), Serdang 43400, Selangor, Malaysia.

Institute of Advanced Technology (ITMA), Universiti Putra Malaysia (UPM), Serdang 43400, Selangor, Malaysia.

出版信息

Sensors (Basel). 2017 Jul 1;17(7):1539. doi: 10.3390/s17071539.

DOI:10.3390/s17071539
PMID:28671562
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5539542/
Abstract

An attractive electrochemical sensor of poly(3,4-ethylenedioxythiophene)/reduced graphene oxide electrode (PrGO) was developed for an electrochemical technique for uric acid (UA) detection in the presence of ascorbic acid (AA). PrGO composite film showed an improved electrocatalytic activity towards UA oxidation in pH 6.0 (0.1 M PBS). The PrGO composite exhibited a high current signal and low charge transfer resistance () compared to a reduced graphene oxide (rGO) electrode or a bare glassy carbon electrode (GCE). The limit of detection and sensitivity of PrGO for the detection of UA are 0.19 μM (S/N = 3) and 0.01 μA/μM, respectively, in the range of 1-300 μM of UA.

摘要

开发了一种具有吸引力的聚（3,4 - 乙撑二氧噻吩）/还原氧化石墨烯电极（PrGO）电化学传感器，用于在抗坏血酸（AA）存在下检测尿酸（UA）的电化学技术。PrGO复合膜在pH 6.0（0.1 M PBS）条件下对UA氧化表现出增强的电催化活性。与还原氧化石墨烯（rGO）电极或裸玻碳电极（GCE）相比，PrGO复合材料表现出高电流信号和低电荷转移电阻（）。在1 - 300 μM的UA范围内，PrGO检测UA的检测限和灵敏度分别为0.19 μM（S/N = 3）和0.01 μA/μM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6e/5539542/b284c28e717c/sensors-17-01539-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6e/5539542/8eeffc36597a/sensors-17-01539-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6e/5539542/6442a4aad1ab/sensors-17-01539-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6e/5539542/f963b9636062/sensors-17-01539-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6e/5539542/e8bc28fc716f/sensors-17-01539-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6e/5539542/be3efa56d767/sensors-17-01539-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6e/5539542/b284c28e717c/sensors-17-01539-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6e/5539542/8eeffc36597a/sensors-17-01539-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6e/5539542/6442a4aad1ab/sensors-17-01539-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6e/5539542/f963b9636062/sensors-17-01539-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6e/5539542/e8bc28fc716f/sensors-17-01539-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6e/5539542/be3efa56d767/sensors-17-01539-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6e/5539542/b284c28e717c/sensors-17-01539-g006.jpg

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