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进化的双刃剑。

The double-edged sword of evolution.

机构信息

Department of Nephrology, Rambam Health Care Campus, Haifa, Israel.

Department of Medical and Research Development, Rambam Heath Care Campus, Haifa, Israel.

出版信息

Elife. 2017 Jul 3;6:e29056. doi: 10.7554/eLife.29056.

DOI:10.7554/eLife.29056
PMID:28671870
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5495566/
Abstract

Two gene variants provide different levels of protection against sleeping sickness, but this comes with an increased risk of developing chronic kidney disease.

摘要

两种基因变异体提供了不同程度的对抗昏睡病的保护，但这也增加了患慢性肾病的风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88e2/5495566/f80333642c60/elife-29056-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88e2/5495566/f80333642c60/elife-29056-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88e2/5495566/f80333642c60/elife-29056-fig1.jpg

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2
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PLoS Pathog. 2014 Nov 6;10(11):e1004469. doi: 10.1371/journal.ppat.1004469. eCollection 2014 Nov.
3
The molecular arms race between African trypanosomes and humans.
Front Med (Lausanne). 2021 Aug 27;8:718300. doi: 10.3389/fmed.2021.718300. eCollection 2021.
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Nat Rev Microbiol. 2014 Aug;12(8):575-84. doi: 10.1038/nrmicro3298. Epub 2014 Jun 30.
4
Evolution of the primate trypanolytic factor APOL1.灵长类动物溶细胞因子 APOL1 的进化。
Proc Natl Acad Sci U S A. 2014 May 20;111(20):E2130-9. doi: 10.1073/pnas.1400699111. Epub 2014 May 7.
5
Mechanism of Trypanosoma brucei gambiense resistance to human serum.冈比亚锥虫对人血清的耐药机制。
Nature. 2013 Sep 19;501(7467):430-4. doi: 10.1038/nature12516. Epub 2013 Aug 21.
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