来自T细胞淋巴瘤的小鼠乳腺肿瘤前病毒的分子克隆与特性分析
Molecular cloning and characterization of mouse mammary tumor proviruses from a T-cell lymphoma.
作者信息
Dudley J P, Arfsten A, Hsu C L, Kozak C, Risser R
出版信息
J Virol. 1986 Jan;57(1):385-8. doi: 10.1128/JVI.57.1.385-388.1986.
Abstract
Five mouse mammary tumor virus proviruses and their flanking cellular DNA sequences have been cloned from a transplanted C57BL/6 (B6) T-cell lymphoma containing additional copies of mouse mammary tumor virus DNA. Characterization of these proviruses and their flanking DNA indicates that B6 lymphomas contain many newly integrated mouse mammary tumor virus copies synthesized by a mechanism(s) which generates polymorphism or deletions or both.
摘要
从一个含有额外小鼠乳腺肿瘤病毒DNA拷贝的移植C57BL/6（B6）T细胞淋巴瘤中克隆出了五个小鼠乳腺肿瘤病毒前病毒及其侧翼细胞DNA序列。对这些前病毒及其侧翼DNA的表征表明，B6淋巴瘤含有许多通过产生多态性或缺失或两者兼有的机制合成的新整合的小鼠乳腺肿瘤病毒拷贝。
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