Piscitelli Alessandra, Cicatiello Paola, Gravagnuolo Alfredo Maria, Sorrentino Ilaria, Pezzella Cinzia, Giardina Paola
Department of Chemical Sciences, Università degli Studi di Napoli Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy.
Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, The University of Manchester, M13 9PT Manchester, UK.
Biomolecules. 2017 Jun 26;7(3):45. doi: 10.3390/biom7030045.
Class I hydrophobins produced from fungi are amongst the first proteins recognized as functional amyloids. They are amphiphilic proteins involved in the formation of aerial structures such as spores or fruiting bodies. They form chemically robust layers which can only be dissolved in strong acids. These layers adhere to different surfaces, changing their wettability, and allow the binding of other proteins. Herein, the modification of diverse types of surfaces with Class I hydrophobins is reported, highlighting the applications of the coated surfaces. Indeed, these coatings can be exploited in several fields, spanning from biomedical to industrial applications, which include biosensing and textile manufacturing.
真菌产生的I类疏水蛋白是最早被认为是功能性淀粉样蛋白的蛋白质之一。它们是两亲性蛋白质，参与孢子或子实体等气生结构的形成。它们形成化学性质稳定的层，只能在强酸中溶解。这些层附着在不同表面上，改变其润湿性，并允许其他蛋白质结合。本文报道了用I类疏水蛋白对多种类型表面进行修饰，突出了涂层表面的应用。事实上，这些涂层可用于从生物医学到工业应用的多个领域，包括生物传感和纺织品制造。
