Perrone Donatella, Fuggetta Maria Pia, Ardito Fatima, Cottarelli Andrea, De Filippis Anna, Ravagnan Giampietro, De Maria Salvatore, Lo Muzio Lorenzo
Department of Clinical and Experimental Medicine, University of Foggia, I-71122 Foggia, Italy.
Institute of Translational Pharmacology, CNR-Area Torvergata, I-00133 Rome, Italy.
Exp Ther Med. 2017 Jul;14(1):3-9. doi: 10.3892/etm.2017.4472. Epub 2017 May 18.
Health promotion strategies and lifestyle changes are important in disease prevention. Oral health has received a large amount of attention previously as it is a fundamental component of general health and it contributes to the quality of life. Therefore, the study of associations between diet, health and the presence of bioactive compounds in food is receiving a substantial amount of attention. In the present review the effects and targets of a natural polyohenolic stilbenoid compound; resveratrol (3,5,4'-trihydroxystilbene; RSV) is assessed, and the future prospects for RSV in promoting oral health are considered. RSV is a phytoalexin, synthesized by a wide range of plants and abundantly extracted in grape skin, it has been purported to exert a multiplicity of anti-inflammatory, anti-viral, anti-microbial, estrogenic, anticancer, cardioprotective, neuroprotective and immunomodulatory functions. In this review, following an introduction documenting the biochemistry of RSV and RSV glucosides, the bioavailability and pharmacokinetics of RSV are described. Considering its multiple properties, the present review has focused on the potential benefits of RSV as an antioxidant and chemopreventive agent.
健康促进策略和生活方式的改变在疾病预防中很重要。口腔健康此前已受到大量关注，因为它是整体健康的基本组成部分，并且对生活质量有影响。因此，饮食、健康与食物中生物活性化合物之间关联的研究正受到大量关注。在本综述中，评估了一种天然多酚类芪化合物——白藜芦醇（3,5,4'-三羟基芪；RSV）的作用和靶点，并探讨了RSV在促进口腔健康方面的未来前景。RSV是一种植物抗毒素，由多种植物合成，在葡萄皮中大量提取，据称具有多种抗炎、抗病毒、抗菌、雌激素样、抗癌、心脏保护、神经保护和免疫调节功能。在本综述中，在介绍了RSV及其糖苷的生物化学之后，描述了RSV的生物利用度和药代动力学。考虑到其多种特性，本综述重点关注了RSV作为抗氧化剂和化学预防剂的潜在益处。
