Song Mingzhi, Zhang Zhen, Liu Tao, Liu Song, Li Gang, Liu Zhaochang, Huang Jingyang, Chen Song, Li Linan, Guo Li, Qiu Yang, Wan Jiajia, Liu Yuejian, Wu Tao, Wang Xiaoyong, Lu Ming, Wang Shouyu
Department of Orthopedics, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China.
Department of Orthopedics, The Third Affiliated Hospital of Dalian Medical University, Jinpu New Area, Liaoning 116200, P.R. China.
Exp Ther Med. 2017 Jul;14(1):531-538. doi: 10.3892/etm.2017.4539. Epub 2017 Jun 1.
Large skin defects are commonly observed in the clinic and have attracted much attention recently. Therefore, finding an effective solution for large skin defects is a global problem. The objective of the present study was to assess the effectiveness of the EASApprox skin-stretching system for closing large skin defects. Skin defects (5×5 cm) were created on the forearms of 9 Bama miniature pigs, which were randomly divided into the following three groups: Direct suture, the new EASApprox skin-stretching device and Kirschner wires. Microcirculation was assessed before surgery and after wound closure. Following the different treatments, the defects were sutured, and wound healing was assessed based on a clinical score. Furthermore, microscopic and ultramicroscopic structures were evaluated, including collagen, elastic fibers and the microvessel density. Significant differences in the clinical score and microvessel density were observed among the groups. Additionally, the mean length obtained for elastic fibers was larger than that obtained for the other two groups. Finally, the new EASApprox skin-stretching device resulted in successful wound management and with only minor side effects on skin histology and microcirculation. Therefore, this method has the potential to be used for healing large skin defects.
临床上常可见到大面积皮肤缺损，近年来已引起广泛关注。因此，寻找治疗大面积皮肤缺损的有效方法是一个全球性问题。本研究的目的是评估EASApprox皮肤拉伸系统闭合大面积皮肤缺损的有效性。在9只巴马小型猪的前臂上制造5×5厘米的皮肤缺损，将其随机分为以下三组：直接缝合组、新型EASApprox皮肤拉伸装置组和克氏针组。在手术前和伤口闭合后评估微循环。经过不同治疗后，对缺损进行缝合，并根据临床评分评估伤口愈合情况。此外，还评估了微观和超微结构，包括胶原蛋白、弹性纤维和微血管密度。各组之间在临床评分和微血管密度方面观察到显著差异。此外，弹性纤维的平均长度比其他两组更长。最后，新型EASApprox皮肤拉伸装置成功实现了伤口处理，对皮肤组织学和微循环仅有轻微副作用。因此，该方法有潜力用于治疗大面积皮肤缺损。
