Rogoyski Oliver M, Pueyo Jose Ignacio, Couso Juan Pablo, Newbury Sarah F
Brighton and Sussex Medical School, Medical Research Building, University of Sussex, Falmer, Brighton BN1 9PS, U.K.
Centro Andaluz de Biología de Desarrollo, CSIC-Universidad Pablo de Olavide, Ctra. de Utrera, Km. 1, Sevilla 41013, Spain.
Biochem Soc Trans. 2017 Aug 15;45(4):895-904. doi: 10.1042/BST20160428. Epub 2017 Jul 3.
Genomic analysis has found that the transcriptome in both humans and features large numbers of long non-coding RNA transcripts (lncRNAs). This recently discovered class of RNAs regulates gene expression in diverse ways and has been involved in a large variety of important biological functions. Importantly, an increasing number of lncRNAs have also been associated with a range of human diseases, including cancer. Comparative analyses of their functions among these organisms suggest that some of their modes of action appear to be conserved. This highlights the importance of model organisms such as , which shares many gene regulatory networks with humans, in understanding lncRNA function and its possible impact in human health. This review discusses some known functions and mechanisms of action of lncRNAs and their implication in human diseases, together with their functional conservation and relevance in development.
基因组分析发现，人类和（此处原文缺失内容）的转录组都有大量的长链非编码RNA转录本（lncRNAs）。这类最近才发现的RNA以多种方式调节基因表达，并参与了各种各样重要的生物学功能。重要的是，越来越多的lncRNAs也与一系列人类疾病相关，包括癌症。对这些生物之间它们功能的比较分析表明，它们的一些作用模式似乎是保守的。这凸显了诸如（此处原文缺失内容）等模式生物的重要性，其与人类共享许多基因调控网络，有助于理解lncRNA功能及其对人类健康可能产生的影响。本综述讨论了lncRNAs的一些已知功能、作用机制及其在人类疾病中的意义，以及它们在（此处原文缺失内容）发育中的功能保守性和相关性。
