药物性QT间期延长与尖端扭转型室性心动过速
Drug-Induced QT Prolongation And Torsades de Pointes.
作者信息
Li Matthew, Ramos Liz G
出版信息
P T. 2017 Jul;42(7):473-477.
Abstract
Torsades de pointes (TdP)-an uncommon but life-threatening polymorphic ventricular tachycardia-is almost always drug induced. The authors describe the causes, risk factors, symptoms, diagnosis, and treatment of TdP.
摘要
尖端扭转型室速（TdP）——一种罕见但危及生命的多形性室性心动过速——几乎总是由药物引起的。作者描述了尖端扭转型室速的病因、危险因素、症状、诊断和治疗方法。
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本文引用的文献
1
2
Drug-induced QT interval prolongation and torsades de pointes: Role of the pharmacist in risk assessment, prevention and management.药物诱导的QT间期延长和尖端扭转型室速：药师在风险评估、预防及管理中的作用
Can Pharm J (Ott). 2016 May;149(3):139-52. doi: 10.1177/1715163516641136. Epub 2016 Apr 8.
3
Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect - comprehensive overview of clinical trials.药物相互作用和QT间期延长作为一种常见的心脏效应评估——临床试验综述
BMC Pharmacol Toxicol. 2016 Mar 10;17:12. doi: 10.1186/s40360-016-0053-1.
4
Drug-induced QT interval prolongation: mechanisms and clinical management.药物致 QT 间期延长：机制与临床处理。
Ther Adv Drug Saf. 2012 Oct;3(5):241-53. doi: 10.1177/2042098612454283.
5
Fluid and electrolyte disturbances in critically ill patients.危重症患者的体液和电解质紊乱
Electrolyte Blood Press. 2010 Dec;8(2):72-81. doi: 10.5049/EBP.2010.8.2.72. Epub 2010 Dec 31.
6
Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation.医院环境中尖端扭转型室速的预防：美国心脏协会和美国心脏病学基金会的科学声明
Circulation. 2010 Mar 2;121(8):1047-60. doi: 10.1161/CIRCULATIONAHA.109.192704. Epub 2010 Feb 8.
7
Long QT syndrome in adults.成人长QT综合征
J Am Coll Cardiol. 2007 Jan 23;49(3):329-37. doi: 10.1016/j.jacc.2006.08.057. Epub 2007 Jan 4.
8
Cardiac repolarization. The long and short of it.心脏复极化。简而言之。
Europace. 2005 Sep;7 Suppl 2(Suppl 2):3-9. doi: 10.1016/j.eupc.2005.05.010.
9
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Int J Cardiol. 2004 Jul;96(1):1-6. doi: 10.1016/j.ijcard.2003.04.055.
10
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