Idon Paul I, Esan Temitope A, Bamise Cornelius T
Oral Health Prev Dent. 2017;15(3):207-214. doi: 10.3290/j.ohpd.a38523.
This study assessed the comparative efficacy of three in-office treatment agents in patients presenting with dentin hypersensitivity (DH) at a university teaching hospital.
A randomised, controlled study was conducted to compare the efficacy of Gluma desensitiser, Pro-Relief and Copal F in relieving the pain of DH. In 68 subjects with 508 hypersensitive teeth, the agents and placebo (distilled water) were applied to 127 hypersensitive teeth each. At baseline, the pain of DH to tactile and evaporative stimuli was measured using the visual analogue scale (VAS) and verbal rating scale (VRS). Post-application assessment was carried out at 10 min, 1 week, 2 and 4 weeks.
The mean difference in VAS between baseline and post-treatment periods significantly increased for all the desensitising agents (p < 0.05) with both tactile and air-blast stimuli, except for the placebo. Gluma desensitiser had the highest mean difference at 10 min (3.7 ± 1.8) and 4 weeks (5.4 ± 2.3) for tactile and air-blast stimuli, respectively. However, using the VAS, no statistical significance was noted in the mean differences between the agents. With the application of Gluma desensitiser, a significantly higher number of teeth had no pain at 4 weeks using the VRS.
Gluma desensitiser can be suggested as an appropriate desensitising agent for in-office treatment of DH.
本研究评估了三种诊室内治疗药物对一所大学教学医院中患有牙本质过敏症（DH）患者的相对疗效。
进行了一项随机对照研究，以比较Gluma脱敏剂、Pro-Relief和珂巴脂F缓解DH疼痛的疗效。在68名患有508颗过敏牙齿的受试者中，将这些药物和安慰剂（蒸馏水）分别应用于127颗过敏牙齿。在基线时，使用视觉模拟量表（VAS）和言语评定量表（VRS）测量DH对触觉和蒸发刺激的疼痛。在10分钟、1周、2周和4周时进行用药后评估。
除安慰剂外，所有脱敏剂在触觉和喷气刺激下，基线期与治疗后时期之间VAS的平均差异均显著增加（p<0.05）。Gluma脱敏剂在10分钟（触觉刺激为3.7±1.8，喷气刺激为5.4±2.3）和4周时的平均差异最高。然而，使用VAS时，各药物之间的平均差异无统计学意义。使用Gluma脱敏剂时，在4周时使用VRS显示无痛的牙齿数量显著更多。
可以建议将Gluma脱敏剂作为诊室内治疗DH的合适脱敏剂。
