Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
School of Medicine, University of Antioquia, Medellín, Colombia.
Allergy. 2018 Jan;73(1):37-49. doi: 10.1111/all.13241. Epub 2017 Aug 11.
To date, a systematic review of the evidence regarding the association between vitamin D and allergic diseases development has not yet been undertaken.
To review the efficacy and safety of vitamin D supplementation when compared to no supplementation in pregnant women, breastfeeding women, infants, and children for the prevention of allergies.
Three databases were searched through January 30, 2016, including randomized (RCT) and nonrandomized studies (NRS). Two reviewers independently extracted data and assessed the certainty in the body of evidence using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach.
Among the 1932 articles identified, one RCT and four NRS were eligible. Very low certainty in the body of evidence across examined studies suggests that vitamin D supplementation for pregnant women, breastfeeding women, and infants may not decrease the risk of developing allergic diseases such as atopic dermatitis (in pregnant women), allergic rhinitis (in pregnant women and infants), asthma and/or wheezing (in pregnant women, breastfeeding women, and infants), or food allergies (in pregnant women). We found no studies of primary prevention of allergic diseases in children.
Limited information is available addressing primary prevention of allergic diseases after vitamin D supplementation, and its potential impact remains uncertain.
迄今为止，尚未对维生素 D 与过敏疾病发展之间的关联进行系统的证据评估。
综述在预防过敏方面，相较于不补充维生素 D，孕妇、哺乳期妇女、婴儿和儿童补充维生素 D 的疗效和安全性。
截至 2016 年 1 月 30 日，我们检索了 3 个数据库，包括随机对照试验（RCT）和非随机研究（NRS）。两位评审员独立提取数据，并使用推荐评估、制定与评价（GRADE）方法评估证据体的确定性。
在确定的 1932 篇文章中，有 1 项 RCT 和 4 项 NRS 符合纳入标准。所有研究的证据体确定性都非常低，这表明孕妇、哺乳期妇女和婴儿补充维生素 D 可能不能降低特应性皮炎（孕妇）、过敏性鼻炎（孕妇和婴儿）、哮喘和/或喘息（孕妇、哺乳期妇女和婴儿）或食物过敏（孕妇）等过敏疾病的发病风险。我们没有发现儿童期过敏疾病一级预防的研究。
目前有关维生素 D 补充后预防过敏疾病的资料有限，其潜在影响尚不确定。
