Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel.
Nat Rev Microbiol. 2015 Oct;13(10):641-50. doi: 10.1038/nrmicro3527.
Unlike lytic phages, temperate phages that enter lysogeny maintain a long-term association with their bacterial host. In this context, mutually beneficial interactions can evolve that support efficient reproduction of both phages and bacteria. Temperate phages are integrated into the bacterial chromosome as large DNA insertions that can disrupt gene expression, and they may pose a fitness burden on the cell. However, they have also been shown to benefit their bacterial hosts by providing new functions in a bacterium-phage symbiotic interaction termed lysogenic conversion. In this Opinion article, we discuss another type of bacterium-phage interaction, active lysogeny, in which phages or phage-like elements are integrated into the bacterial chromosome within critical genes or operons and serve as switches that regulate bacterial genes via genome excision.
与裂解性噬菌体不同，进入溶原状态的温和噬菌体与其细菌宿主保持长期的联系。在这种情况下，可以进化出互利的相互作用，从而支持噬菌体和细菌的高效繁殖。温和噬菌体作为大型 DNA 插入物整合到细菌染色体中，可能会破坏基因表达，并对细胞的适应性产生负担。然而，它们也被证明通过在称为溶原性转换的细菌-噬菌体共生相互作用中提供新的功能而使细菌宿主受益。在这篇观点文章中，我们讨论了另一种细菌-噬菌体相互作用，即活性溶原性，其中噬菌体或类噬菌体元件整合到细菌染色体中的关键基因或操纵子内，并作为通过基因组切除调节细菌基因的开关。
