Department of Clinical Radiology, University Hospital Münster, Albert-Schweitzer-Campus 1, Münster, 48149, Germany.
Institute of Legal Medicine, University Hospital Münster, Röntgenstraße 23, Münster, 48149, Germany.
Eur Radiol. 2017 Dec;27(12):5041-5048. doi: 10.1007/s00330-017-4880-2. Epub 2017 Jul 4.
To clarify the relevance of the bony fusion of the distal femoral and the proximal tibial epiphyses by means of magnetic resonance imaging (MRI), a prospective cross-sectional cohort study was performed with a special focus on a reliable determination of the 14th, 16th and 18th years of life.
We scanned 658 German volunteers in the age bracket 12-24 years using a 3.0 T MR-scanner and utilising a T1 turbo spin-echo sequence representing true bone anatomy. Minimum, maximum, mean ± standard deviation and median with lower and upper quartiles were defined. Intra- and interobserver agreements were determined (Cohen's kappa). The statistical relevance of sex-related differences was analysed (Mann-Whitney U test, p < 0.05, exact, two-sided).
The bony fusion took place before the 18th year of life in both epiphyses. The Mann-Whitney U test results imply significant sex-related differences for most stages. For both epiphyses, the intra observer (κ femur 0.961; tibia 0.971) and interobserver (κ femur 0.941; tibia 0.951) agreement levels were very good.
The 14th and the 16th years of life can be determined in both sexes, but the completion of the 18th year of life cannot solely be determined by the bony fusion, as depicted by closest-to-bone MRI.
• Forensic age estimation by means of MRI of the knee is feasible. • MRI provides data about the ossification process without using ionising radiation. • The method allows the determination of the 14th and 16th years of life. • The bony fusion is not suitable as the sole indicator of majority. • The chosen classification is easy to use for specially trained professional personnel.
通过磁共振成像(MRI)明确股骨远端和胫骨近端骨骺骨融合的相关性,我们进行了一项前瞻性的横断面队列研究,特别关注于可靠地确定 14 岁、16 岁和 18 岁。
我们使用 3.0 T 磁共振扫描仪对 658 名年龄在 12 至 24 岁的德国志愿者进行扫描,并利用 T1 涡轮自旋回波序列来表示真实的骨骼解剖结构。定义了最小值、最大值、平均值±标准差和中位数以及下四分位数和上四分位数。确定了观察者内和观察者间的一致性(Cohen's kappa)。分析了性别差异的统计学相关性(Mann-Whitney U 检验,p<0.05,精确,双侧)。
在两个骨骺中,骨融合都发生在 18 岁之前。Mann-Whitney U 检验结果表明,大多数阶段都存在显著的性别差异。对于两个骨骺,观察者内(κ 股骨 0.961;胫骨 0.971)和观察者间(κ 股骨 0.941;胫骨 0.951)的一致性水平都非常好。
在两性中都可以确定 14 岁和 16 岁,但仅通过最接近骨骼的 MRI 所示的骨融合不能单独确定 18 岁的成年。
· 通过膝关节 MRI 进行法医年龄估计是可行的。
· MRI 提供了关于骨化过程的数据,而无需使用电离辐射。
· 该方法允许确定 14 岁和 16 岁。
· 骨融合不适合作为成年的唯一指标。
· 所选分类易于受过专门培训的专业人员使用。