Institute of Clinical Radiology, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Clinic for Radiology, Klinikum Ibbenbüren, Große Straße 41, 49477, Ibbenbüren, Germany.
Eur Radiol. 2018 Aug;28(8):3255-3262. doi: 10.1007/s00330-017-5281-2. Epub 2018 Mar 13.
To explore the possibility of determining majority via a morphology-based examination of the epiphyseal-diaphyseal fusion by 3.0 T magnetic resonance imaging (MRI), a prospective cross-sectional study developing and applying a new stage classification was conducted.
344 male and 350 female volunteers of German nationality between the ages of 12-24 years were scanned between May 2013 and June 2015. A 3.0 T MRI scanner was used, acquiring a T1-weighted (T1-w) turbo spin-echo sequence (TSE) and a T2-weighted (T2-w) TSE sequence with fat suppression by spectral pre-saturation with inversion recovery (SPIR). The gathered information was sifted and a five-stage classification was formulated as a hypothesis. The images were then assessed using this classification. The relevant statistics were defined, the intra- and interobserver agreements were determined, and the differences between the sexes were analysed.
The application of the new classification made it possible to correctly assess majority in both sexes by the examination of the epiphyses of the knee joint. The intra- and interobserver agreement levels were very good (κ > 0.80). The Mann-Whitney-U Test implied significant sex-related differences for most stages.
Applying the presented MRI classification, it is possible to determine the completion of the 18th year of life in either sex by 3.0 T MRI of the knee joint.
• Based on prospective referential data a new MRI classification was formulated. • The setting allows assessment of the age of an individual's skeletal development. • The classification scheme allows the reliable determination of majority in both sexes. • The staging shows a high reproducibility for instructed and trained professional personnel. • The proposed classification is likely to be adaptable to other long bone epiphyses.
通过 3.0T 磁共振成像（MRI）对骺-干融合的形态学检查来探索确定多数的可能性，进行了一项前瞻性的横断面研究，开发并应用了一种新的分期分类。
2013 年 5 月至 2015 年 6 月，对 344 名男性和 350 名德国国籍的 12-24 岁志愿者进行扫描。使用 3.0T MRI 扫描仪，获取 T1 加权（T1-w）涡轮自旋回波（TSE）序列和 T2 加权（T2-w）TSE 序列，通过频谱预饱和反转恢复（SPIR）进行脂肪抑制。收集的信息进行筛选，并提出了一个五期分类作为假设。然后使用该分类评估图像。定义了相关的统计数据，确定了观察者内和观察者间的一致性，并分析了性别差异。
新分类的应用使得通过膝关节骺的检查可以正确评估两性的多数。观察者内和观察者间的一致性水平非常好（κ>0.80）。Mann-Whitney-U 检验表明大多数阶段都存在显著的性别相关差异。
应用所提出的 MRI 分类，通过膝关节 3.0T MRI 可以确定两性中第 18 年的生活完成情况。
• 根据前瞻性参考数据制定了新的 MRI 分类。• 设置允许评估个体骨骼发育的年龄。• 分类方案允许可靠地确定两性中的多数。• 分期对于受过指导和训练的专业人员具有很高的可重复性。• 拟议的分类可能适用于其他长骨骺。
